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CCTG Connection



Published:
Category: Publications
Publication: MA38 primary
MA38 primary publication Continuous versus Standard Palbociclib Treatment and Molecular Profiling of Solid Tissues and Liquid Biopsies in the CCTG MA.38 Trial in Advanced Breast Cancer.
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Published:
Category: Publications
QoL Substudy GA2
The INTEGRATE trials evaluated regorafenib in advanced gastric and esophagogastric junction cancer (AGOC), a poor prognosis population. In INTEGRATE 1 (I1, phase 2), regorafenib improved progression-free survival (PFS) without a clear excess decline in health-related quality of life (HRQoL). INTEGRATE 2a (I2a, phase 3) demonstrated an overall survival (OS) benefit, alone and in a pre-specified pooled analysis with I1.
 
Martin AJ, Soon YY, Sjoquist KM, Pavlakis N, Goldstein D, Shitara K, Simes JR.
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Published:
Category: Publications
Publication: Secondary analysis IND223, IND232 and IND234
Secondary analysis publication using data from IND223, IND232 and IND234.
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Published:
Category: Group updates
CCTG at the Canadian Cancer Research Conference 2025

The Canadian Cancer Research Conference (CCRC) 2025 was held from November 2 to November 4 in Calgary and brings together the Canadian cancer research community for an agenda spanning the research spectrum.  The biennial CCRC is organized by the Canadian Partnership Against Cancer under the direction of the Canadian Cancer Research Alliance (CCRA). 

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Published:
Category: News
For cancer, exercise could be the key to recovery

Sharing a great opinion piece related to the CO21 Challenge trial.


OPINION: The Globe and Mail  - Oct 28, 2025

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Published:
Category: Publications
Publication: BRC5
BRC5 (Alliance B140503) secondary analysis publication:  Additional node dissection in the BRC5 trial was performed at the surgeon's discretion and included simple sampling, systematic sampling, or complete lymph node dissection. Researchers report the impact of the extent of lymphadenectomy on disease- and recurrence-free survival in this trial.
 
Altorki N, Damman B, Wang X, Liberman M, Wigle D, Ashrafi A, Conti M, Yasufuku K, Schuchert MJ, Stinchcombe TE.
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Published:
Category: Publications
Publication: MAC20 secondary analysis
Obesity is associated with a higher risk of recurrence, mortality, comorbidities, treatment-related adverse effects, and poor quality of life in patients with breast cancer. Scalable interventions are needed to promote weight loss in this population. Can a remotely delivered weight loss intervention (WLI) reduce weight in a diverse population of women with breast cancer and a body mass index of 27 or higher? Read More

Published:
Category: Trials
Trial closure: LY16

The LY16 (LYSARC RELEVANCE) phase III open-label randomized study to compare the efficacy and safety of rituximab plus lenalidomide (CC-5013) versus rituximab plus chemotherapy followed by rituximab in subjects with previously untreated follicular lymphoma trial is permanently closed.

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