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CCTG Connection



Published:
Category: Group updates
CCTG Tissue Bank Holiday Season Notice:

Shipment of Specimens for Banking + Kit Supply

To all centres participating on trials where frozen fluids (blood, serum, plasma, urine, etc.) and formalin fixed paraffin embedded tissues (FFPE tumour blocks, slides, etc.) are collected and banked at the CCTG Tissue Bank:

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Published:
Category: News
Congratulations to Florencia Comelles and Claire Norman

For over seven years the Dr. Frances Shepherd Award has supported investigators or post-graduate trainees who's CCTG research project demonstrates excellence in clinical trials and translational research. This Award provides travel support to present CCTG work at major international and national meetings. The CCTG Scientific Leadership selection task force have recently announced two new Award recipients, congratulations to Florencia Comelles and Claire Norman who will be formally presented their award at the CCTG Spring Meeting 2026.

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Published:
Category: Publications
Publication: BLC4 secondary analysis
CCTG BLC4 (SWOG S1605) Urine Tumor DNA to Stratify the Risk of Recurrence
 
This study demonstrates that urine tumor DNA profiling can be used to stratify the risk of recurrence in patients after treatment with atezolizumab for bacillus Calmette-Guérin–unresponsive non–muscle-invasi
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Published:
Category: Publications
Publication: CO7 meta analysis
CO7 - systemic chemotherapy for patients with resectable or resected colorectal cancer liver metastases: An individual patient data meta-analysis of individual patient data from randomised phase III trials comparing surgery plus systemic chemotherapy with surgery alone in patients with CRCLM. Analyses were performed in the overall intention-to-treat (ITT) population, in patients who had curative-intent surgery (resected population), and in those who received post-operative chemotherapy only.
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Published:
Category: Publications
Publication: EN10 EN11  Barriers to Implementation

Endometrial Carcinoma Molecular Classification and Barriers to Implementation, Possible Solutions, and the Implications for Ongoing Clinical Trials. 

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Published:
Category: Publications
Publication: IND227 updated analysis
Abstract IND.227 oral presentation at the World Conference on Lung Cancer in Barcelona, Spain, on 8 September, 2025. Subsequently published in the Journal of Thoracic Oncology.
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Published:
Category: Publications
Publication: MA38 primary
MA38 primary publication Continuous versus Standard Palbociclib Treatment and Molecular Profiling of Solid Tissues and Liquid Biopsies in the CCTG MA.38 Trial in Advanced Breast Cancer.
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Published:
Category: Publications
QoL Substudy GA2
The INTEGRATE trials evaluated regorafenib in advanced gastric and esophagogastric junction cancer (AGOC), a poor prognosis population. In INTEGRATE 1 (I1, phase 2), regorafenib improved progression-free survival (PFS) without a clear excess decline in health-related quality of life (HRQoL). INTEGRATE 2a (I2a, phase 3) demonstrated an overall survival (OS) benefit, alone and in a pre-specified pooled analysis with I1.
 
Martin AJ, Soon YY, Sjoquist KM, Pavlakis N, Goldstein D, Shitara K, Simes JR.
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