The Canadian Cancer Trials Group Central Operations and Statistics Centre will be closed on Monday, July 1, 2019 for Canada Day. Regular business hours will resume on Tuesday, July 2 at 8:30 am EDT.

Independent Investigational New Drug Program

 Independent Investigational New Drug Program
Testing new drugs

Cancer clinical trials provide information about the safety and efficacy of potential medicines, how they should be used and who can benefit from them. Without the proof that these drugs work or work better than current treatments, then new options would not be available for patients. The researchers in the Investigational New Drug (IND) and Phase III Programs at CCTG identify promising new drugs for patients with cancer. The group conducts early trials (Phase I and II) that pave the way for larger Phase III trials identifying new and improved standard treatments.

CCTG trials are entirely independently conducted, analyzed and reported. Pharmaceutical or academic drug manufacturers provide CCTG access to their investigational drugs because they recognize the high quality research being conducted through the group. Drug partners may receive reports on the progress of trials involving their product but they do not play any role in the day to day conduct, nor analysis of any CCTG clinical trial.

Governance and independence

The Investigational New Drug (IND) Committee, IND Executive, the Early Trials Advisory Group and Clinical Trials Committee advise on the selection and overall direction of new drug studies while the  Data Safety Monitoring Committee ensures patient safety. Members on these CCTG national committees represent the views of their cancer centres and their patients regarding potential benefits and feasibility of proposed studies.

Members of CCTG’s IND Program Executive (Phase I and II) and Clinical Trials Committee (Phase III trials) are leading Canadian academic researchers, lay representatives, pharmacists and research nurses who review and prioritize promising drugs for testing and oversee the conduct of CCTG led trials.

There are no pharmaceutical company or commercial representatives on any of these governance committees. All CCTG clinical trials, at all stages, are peer reviewed during grant process by national and international independent peer teams. Many trials are also subject to peer review during submissions for individual grants to support a specific trial.

Canadian Cancer Trials Lesley Seymour IND Director

Why drug trials matter

CCTG scientists have earned a reputation for changing cancer treatment practices around the world. Part of their secret is that they ask the right questions and take a scientific approach to find the right answers.

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Dr. John Hilton, the Study Co-Chair of IND.231, gave an oral presentation

IND.231 presented at the Targeted Anti-Cancer Therapies (TAT) International Congress 2018

Dr. John Hilton, the Study Co-Chair of IND.231, gave an oral presentation of the results to date from IND.231, A Phase I/II Study of CX-5461, at the Targeted Anti-Cancer Therapies (TAT) International Congress 2018 - "the home of phase I in oncology". The conference was held in Paris, France on March 5-7, 2018.

TAT focuses on early-phase development and translational research. The programme covers targeted agents, immuno-oncology and combinations involving such agents.

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