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CCTG Connection



Published:
Category: Group updates
Health Canada publishes GUI-0100 version 4

 

On August 14, 2026 Health Canada released an updated guidance that replaces Guidance Document: Part C, Division 5 of the Food and Drug Regulations "Drugs for Clinical Trials Involving Human Subjects" (GUI-0100), version 3

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Published:
Category: Group updates
Seeking Patient Representative for the Breast Disease Site Committee
The Canadian Cancer Trials Group (CCTG) is currently seeking applications for a Patient Representative for the Breast Disease Site Committee. CCTG is an inclusive organization dedicated to building a diverse national network, so we are strongly considering applications for patient representation from Quebec, New Brunswick, Nova Scotia, PEI or Newfoundland and Labrador for this position. Read More

Published:
Category: Publications
Publication: non-small cell lung cancer review
Association of tumor mutational burden and tumor-infiltrating lymphocytes with second primary cancer after complete resection of non-small cell lung cancer
 
The risk of developing second primary cancers (SPC) after complete surgical resection of non-small cell lung cancer (NSCLC) has been estimated at 1-2% per patient-year.
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Published:
Category: Publications
Publication: VU2 review
 Vulvar Squamous Cell Carcinoma: Scientific Progress and Impacts to Pathology Practice
 
Despite vulvar cancer’s rarity, meaningful advances have been made to improve the clinical care of affected patients—particularly with respect to vulvar squamous cell carcinoma (VSCC). These advances are reflected in changes to tumor classification, surgical strategies, early detection of precursors, and targeted therapeutic exploration.
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Published:
Category: Trials
Trial closure:  SRC6
The SRC.6 (COG ARST1321) Pazopanib Neoadjuvant Trial in Non-Rhabdomyosarcoma Soft Tissue Sarcomas (PAZNTIS): A Phase II/III Randomized Trial of Preoperative Chemoradiation or Preoperative Radiation Plus or Minus Pazopanib has permanently closed.
 
This trial studies how well pazopanib, when combined with chemotherapy and radiation therapy or radiation therapy alone, work in the treatment of patients with newly diagnosed non-rhabdomyosarcoma soft tissue sarcomas that can
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Published:
Category: Publications
Publication: GA1 secondary analysis

Older adults with resectable gastric cancer undergoing perioperative chemotherapy or preoperative chemoradiotherapy plus perioperative chemotherapy: A secondary analysis of the AGITG TOPGEAR phase III trial

This secondary analysis evaluated the treatment adherence, adverse events, and survival in older (≥70 years) adults undergoing perioperative treatment for gastric cancer.

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Published:
Category: Publications
Publication: PA7 substudy
Clinical and Molecular Correlates of Circulating Tumor Fraction in Patients with Metastatic Pancreatic Ductal Adenocarcinoma
 
Pre-existing and emerging molecular targeted therapies have been identified for the treatment of pancreatic ductal adenocarcinoma (PDAC) and exemplify the need for incorporating tumor sequencing into routine clinical practice. Tumor profiling through circulating tumor DNA (ctDNA) represents an important opportunity in PDAC because of the aggressive nature of the disease.
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Published:
Category: Trials
PAC5 trial is open to postoperative pancreatic patient enrollment

The CCTG PAC5 trial is now open to patient enrollment in Canada. The trial is evaluating whether lanreotide can reduce the risk of postoperative pancreatic fistula (POPF), one of the most important complications following pancreatic surgery. A pancreatic fistula occurs when pancreatic fluid leaks from the surgical connection or cut surface of the pancreas after an operation. While some leaks are relatively minor, clinically significant POPF can lead to serious complications, including infection, abscess formation and bleeding.

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