To develop and conduct clinical trials aimed at improving the treatment and prevention of cancer with the ultimate goal of reducing morbidity and mortality from this disease.

About Us

The Canadian Cancer Trials Group is a cooperative oncology group which carries out clinical trials in cancer therapy, supportive care and prevention across Canada and internationally. It is one of the national programmes and networks of the Canadian Cancer Society Research Institute (CCSRI), and is supported by the Canadian Cancer Society (CCS).

Faculty Researchers

Meet the Faculty Researchers


The information contained in this website is intended for use by Canadian Cancer Trials Group members at participating centres.

Recently Activated

  • CO28 
    NEOadjuvant Chemotherapy, Excision and Observation for Early Rectal Cancer: The NEO Trial
  • HN9 
    Randomized Phase II Study of Cisplatin plus Radiotherapy versus Durvalumab plus Radiotherapy followed by Adjuvant Durvalumab versus Durvalumab plus Radiotherapy followed by Adjuvant Tremelimumab and Durvalumab in Intermediate Risk HPV-Positive Locoregionally Advanced Oropharyngeal Squamous Cell Cancer (LA-OSCC)
  • I234 
    Prostate Cancer Biomarker Enrichment and Treatment Selection (PC_BETS) Study - Master Screening Protocol
  • MAC21 
    A Randomized Phase III Double Blinded Placebo Controlled Trial of Aspirin as Adjuvant Therapy for HER2 Negative Breast Cancer: The ABC Trial
  • MAC22 
    Tomosynthesis Mammographic Imaging Screening Trial (TMIST)
  • PM1 
    CAnadian Profiling and Targeted agent Utilization tRial (CAPTUR)
  • Planned Trials

  • ALC5 
    A Randomized Phase II/III Trial of Novel Therapeutics versus Azaciticine in Newly Diagnosed Patients with Acute Myeloid Leukemia or High Risk Myelodysplastic Syndrome, Aged 60 or Older (LEAP, Intergroup Less Intense AML Platform Trial)
  • BLC3 
    A Phase III Randomized Trial to Evaluate the Influence of BCG Strain Differences and T cell Priming with Intradermal BCG Before Intravesical Therapy for BCG-naive High-grade Non-muscle Invasive Bladder Cancer
  • CE7 
    A Phase III Trial of Stereotactic Radiosurgery compared with Whole Brain Radiotherapy (WBRT) for 5-15 Brain Metastases
  • MA39 
    Tailor RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low Risk Node Positive Breast Cancer
  • MAC23 
    Phase III Randomized Trial of Hypofractionated Post-Mastectomy Radiation with Breast Reconstruction
  • OV25 
    A Study of Acetylsalicylic (ASA) in Prevention of Ovarian Cancer in Women with BRCA 1/2 Mutations
  • PNC1 
    InPACT: International Penile Advanced Cancer Trial
  • REC4 
    A Phase III RandOmized Study Comparing PERioperative Nivolumab vs. Observation in Patients with Localized Renal Cell Carcinoma Undergoing Nephrectomy (PROSPER RCC)