Landmark clinical trial reports 33% prostate cancer survival benefit from novel hormone therapy

Presented at ASCO 2019 the landmark ENZAMET | CCTG PR17 (NCT02446405) clinical trial demonstrated that hormone therapy with a drug called enzalutamide can improve the survival of some men with advanced, hormone‐sensitive prostate cancer. Findings, show that men with this sort of cancer who receive enzalutamide with standard treatment have a 33% improvement in survival compared to men receiving standard treatment alone.

“The benefits of enzalutamide had already been established for prostate cancers that are no longer responding to hormonal therapy,” said ENZAMET study co-chair, Professor Ian Davis from the lead group the Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP). “The actual result in patients starting hormonal therapy noted that patients had a 60% improvement in the time it takes to detect the cancer growing again along with a 33% increase chance of survival was far higher than we expected.”

“This data represents an important advance in our knowledge of how to treat this stage of prostate cancer and we look forward to longer term follow-up data on survival and treatment side effects as well as quality of life,” says CCTG Senior Investigator Dr. Wendy Parulekar.