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Trials in Development

This quarter's most recent list of pending trials with general time frames to expected activation. 

Past reports

The planned and recently activated trials lists below is the most up to date and is dynamically generated from our database. 

Planned trials

ALC11

Phase II Trial of ASTX727 and Venetoclax Compared with ASTX727, Venetoclax, and Enasidenib for New Diagnosed Older Adults with IDH2 Mutant AML - A myeloMATCH Substudy

ALC9

Eradicating MRD in Patients with AML prior to Stem Cell Transplant (ERASE)

BI4

Investigating Precision Medicine in the Adjuvant setting: a phase III Clinical Trial in Biliary tract cancer (SAFIR IMPACT BTC)

BR39

LUNA-2: LND101 in Unresectable Non-Small Cell Lung Cancer: A Randomized Phase II Trial

EN12

RAINBO-ORANGE: Treatment of Endometrial Cancer Based On Molecular Features

HN14

Delayed Reduced Volume and Dose Elective Radiotherapy (REVERT) in Patients with HNSCC

MA42

No Chemotherapy in Intermediate-risk HR + HER2- Early Breast Cancer Treated with Ribociclib (NoLEEta)

MD1

Combination Therapy with Luspatercept in Lower Risk Myelodysplasia: A Tier 1 myeloMATCH Substudy

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ME18

Selective Index Node Resection vs Lymph Node Dissection after Neoadjuvant Immunotherapy for Stage IIIB-D Melanoma The Multicentre Selective Lymphadenectomy Trial-3 (MSLT-3)

SR8

NeoAdjuvant-only or Peri-operative cemiplimab in high-grade localised soft-tissue SARcoma (NAPStAR)

MAC32

Rx Therapy Guided by Genomic Risk Assessment For High Anatomic Stage ER+/HER2- Breast Cancer with Recurrence Score ≤ 25 (RxFINE-Low)

GC1

MiRNA371-Guided MAnagement in Testicular germ cell tumors- MAGMA GCT

ME19

Adjuvant tebentafusp (IMCgp100) vs obs in HLA-A*02:01 positive patients following definitive treatment of high-risk uveal melanoma (ATOM Trial)

Recently activated

ALC10

Venetoclax and HMA-based Therapies for the Treatment of Older and Unfit Adults with Newly Diagnosed FLT3-mutated AML: A myeloMATCH Treatment Trial

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CE10

VIGOR: Vorasidenib as Maintenance Treatment after First-line Chemoradiotherapy in IDH-mutant Grade 2 or 3 Astrocytoma

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LYC2

Autologous Stem Cell Transplant in Peripheral T Cell Lymphoma that Achieved a First Complete Remission (CR1) Following Induction Therapy (PTCL-STAT)

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PAC5

Lanreotide for the Prevention of Postoperative Pancreatic Fistula

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SC30

Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Platform Trial - RATIONAL-PT

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SC31

Using SMART to optimize the stepped care delivery of TEMPO – a Tailored, dyadic, wEb-based physical activity and self-Management PrOgram for men with prostate cancer and their caregivers (TEMPO)

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SC32S

Feasibility, Acceptability and Representativeness: Collecting Sociodemographic Data in CCTG Trials

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Patients Stories

The first two CCTG led cell therapy trials are now open in Canada

The first two CCTG led cell therapy trials are now open in Canada

CCTG is committed to the evaluation of innovative cell therapy products, strategies to improve cell therapy outcomes and to advancing accessibility for Canadian patients. IND246 study is a phase I trial evaluating increasing dose levels of GCAR1 and IND245 is a trial evaluating the addition of sonrotoclax and zanubrutinib in patients with mantle cell lymphoma.

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New SC32S survey study opens across Canada

New SC32S survey study opens across Canada

A new survey study SC32S, collecting sociodemographic data from clinical trial participants, has now opened across Canada. This study will help researchers understand the feasibility of using a survey to gather information about trial participants’ backgrounds and everyday lives.

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The BR38 trial testing targeted radiotherapy added to immunotherapy to improve outcomes for lung cancer patients.

The BR38 trial is testing targeted radiotherapy added to immunotherapy to improve outcomes for lung cancer patients

The recently opened BR38 clinical trial is exploring whether adding stereotactic body radiotherapy (SBRT) to the current treatment of immunotherapy (with or without chemotherapy) can improve outcomes for patients with metastatic non-small cell lung cancer (NSCLC) and limited disease progression (oligoprogression).

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New trial SKC1 is testing the neoadjuvant addition of an immunotherapy drug for advanced skin cancer

New trial SKC1 is testing the neoadjuvant addition of an immunotherapy drug for advanced skin cancer

The SKC1 skin cancer clinical trial is now open to enrollment across Canada. This study aims to determine whether adding an immunotherapy drug prior to the standard surgical treatment for advanced skin cancer can improve patient outcomes. This study addresses a substantial unmet need in this patient population.

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