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Brain Clinical Trials

A brain cancer clinical trial - CE9
Trial Code: CE9 ǀ ACTRN: 12623000096651
Disease Site: Brain Clinical Trials

What is the purpose of this study?

This trial is being done to answer the following question: Can survival be improved in your type of brain cancer by using personalized therapy based on changes in the DNA of your tumour? A pre-study screening will test a sample of your tumour tissue for biomarkers to see if you can participate in the study.

 

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Breast Clinical Trials

A breast cancer clinical trial - MAC27
Trial Code: MAC27 | NCT04457596
Disease Site: Breast Clinical Trials

What is the purpose of this study?

The purpose of this study is to find out if the combination of a new drug and a commonly used drug is better than the commonly used drug alone at preventing this type of breast cancer from returning.

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A breast cancer clinical trial - MAC29
Trial Code: MAC.29 ǀ NCT05812807
Disease Site: Breast Clinical Trials

What is the purpose of this study?

The purpose of this study is to determine if observation after surgery is as effective as completing 6 more months of immunotherapy in patients with early-stage triple-negative breast cancer (TNBC) who have completed standard treatment before surgery and who have had a good response.

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A breast cancer clinical trial - MAC28
Trial Code: MAC.28 ǀ NCT04852887
Disease Site: Breast Clinical Trials

What is the purpose of this study?

The purpose of this study is to compare the usual treatment of breast radiation and hormonal drugs after lumpectomy to using hormonal drugs alone for 50 to 70 year old people with low risk breast cancer. The removal of breast radiation from the usual treatment may have no effect on whether your cancer returns, and it could also reduce side effects.

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A breast cancer clinical study - MAC26
Trial Code: MAC.26 ǀ NCT03598257
Disease Site: Breast Clinical Trials

What is the purpose of this study?

The purpose of this study is to find out if a new drug helps prevent your inflammatory breast cancer from returning when given with radiotherapy.

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A breast cancer clinical trial - MAC30
Trial Code: CCTG MAC.30 ǀ NCT05879926
Disease Site: Breast Clinical Trials

What is the purpose of this study?

The purpose of this study is to compare two commonly used treatment choices for early-stage breast cancer in premenopausal women. Testing the addition of chemotherapy to the usual treatment of ovarian function suppression plus hormonal therapy in premenopausal ER-positive/HER2-negative breast cancer patients who are at high risk of cancer returning.

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Gastro-Intestinal Clinical Trials

A pancreatic cyst clinical trial - PAC4
Trial Code: PAC.4 ǀ NCT04239573
Disease Site: Gastro-Intestinal Clinical Trials

What is the purpose of this study?

The purpose of this study is to determine which approach, less frequent or more frequent monitoring, will lead to better outcomes for patients with pancreatic cysts.

Why is this study important?

Currently, the effectiveness of any pancreatic cyst monitoring strategy is unknown. Patients and physicians are eager to learn which strategy is better for this very common condition.

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A neuroendocrine cancer clinical trial - NE2
Trial Code: NE2 (STOPNET) l NCT06345079
Disease Site: Gastro-Intestinal Clinical Trials

What is the purpose of this study?

The purpose of this study is to compare the usual approach of continuing Somatostatin Analogues (SSA) injections during and after Peptide Receptor Radionuclide Therapy (PRRT) to stopping SSA injections when PRRT begins in patients with neuroendocrine tumours (NET).

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A gastroesophageal clinical trial - GA4
Trial Code: GA.4 ǀ NCT06043427
Disease Site: Gastro-Intestinal Clinical Trials

What is the purpose of this study?

The purpose of this study is to find out what effects adding a new drug to the standard treatment has on you and your gastroesophageal cancer compared to the standard treatment given alone.

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An esophageal cancer clinical trial - ES3
Trial Code: ES.3 (NEEDS) ǀ EudraCT 2020-000149-15
Disease Site: Gastro-Intestinal Clinical Trials

What is the purpose of this study?

The purpose of this study is to find out if the approach of avoiding or delaying surgery in patients who have a good response to treatment with chemotherapy and radiation is as good as the usual approach for your esophageal cancer and provides better quality of life.

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A colon cancer study - CRC10
Trial Code: CRC.10 ǀ NCT 05174169
Disease Site: Gastro-Intestinal Clinical Trials

What is the purpose of this study?

The purpose of this study is to test if we can determine what kind of chemotherapy to offer patients based on whether or not circulating tumour DNA (ctDNA) is found in a blood test taken after surgery for colon cancer.

Why is this study important?

Using ctDNA testing to determine what kind of chemotherapy to use is a new approach. This approach seems promising, but it is not clear if it can offer better results than standard treatment.

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A rectal cancer clinical trial - CO32
Trial Code: CO.32 (NEO-RT) ǀ NCT06205485
Disease Site: Gastro-Intestinal Clinical Trials

What is the purpose of this study?

The purpose of this study is to compare the usual approach of chemotherapy plus radiation therapy followed by limited surgery, to using a more intense combination chemotherapy treatment followed by limited surgery.

The study approach without radiation may improve your quality of life and be equally effective at shrinking or stabilizing your cancer.

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A neuroendocrine cancer clinical trial - NE1
Trial Code: CCTG NE.1 (NET RETREAT) ǀ NCT05773274
Disease Site: Gastro-Intestinal Clinical Trials

What is the purpose of this study?

The purpose of this study is to compare a retreatment with Peptide Receptor Radionuclide Therapy (PRRT) to the standard treatment for your neuroendocrine cancer.

Why is this study important?

The drug being studied is a new type of drug approved for the treatment of neuroendocrine tumours (NETs). The new drug has been shown to shrink tumours in many people and seems promising, but it is not clear if receiving this drug again can offer better results than standard treatment.

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Genito-Urinary Clinical Trials

An advanced prostate cancer clinical trial - PR25
Trial Code: PR.25 ǀ NCT06439225
Disease Site: Genito-Urinary Clinical Trials

What is the purpose of this study?

The purpose of this study is to compare the effects on you and your prostate cancer of a new drug compared to other drugs which are the current standard treatment for this disease. The addition of the new drug to standard treatment could prevent your prostate cancer from progressing, but this cannot be known for sure. This study will help doctors find out if this different approach is better than the usual one.

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A prostate cancer clinical trial - PR24
Trial Code: PR.24 ǀ NCT06235697
Disease Site: Genito-Urinary Clinical Trials

What is the purpose of this study?

The purpose of this study is to compare the effects on you and your prostate cancer of getting a higher dose of radiation therapy given over a shorter period of time compared to the current way radiation therapy is used to treat prostate cancer.

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A metastatic urothelial cancer clinical trial - BLC5
Trial Code: BLC5 ǀ NCT05092958
Disease Site: Genito-Urinary Clinical Trials

What is the purpose of this study?

The purpose of this study is to see if adding a new drug to other drugs which are commonly used to treat metastatic urothelial cancer is better than the commonly used drugs alone.

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Gynecology Clinical Trials

A gynecological cancer clinical trial - VU2
Trial Code: VU.2 ǀ NCT06358469
Disease Site: Gynecology Clinical Trials

What is the purpose of this study?

The purpose of this study is to evaluate if specific testing of vulva cancer tissue that is removed by surgery provides useful information to help decide if additional surgery is required or not.

Why is this study important?

The usual approach to treating early-stage vulvar cancer consists of a single surgery to remove the cancer.

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A gynecological cancer clinical trial - EN10
Trial Code: EN10 | NCT05640999
Disease Site: Gynecology Clinical Trials

What is the purpose of this study?

The purpose of this study is to identify people who may not require treatment after surgery or may require less treatment after surgery because their cancer is at such a low risk of coming back based on the specific tumour features found by the laboratory testing and the extent of tumour spread. Receiving no treatment or less treatment can result in no or fewer side effects (fatigue, hair loss, bowel and bladder irritation).

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An endometrial cancer study - EN11
Trial Code: CCTG EN.11 ǀ NCT05255653
Disease Site: Gynecology Clinical Trials

What is the purpose of this study?

The purpose of this study is to compare the effects on you and your endometrial cancer of a new drug in combination with radiation therapy compared to the current standard treatment of radiation therapy alone.

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Head and Neck Clinical Trials

A head and neck cancer clinical trial - HN11
Trial Code: HN11 ǀ NCT05451004
Disease Site: Head and Neck Clinical Trials

What is the purpose of this study?

The purpose of this study is to compare the effects on you and your oropharyngeal cancer of radiotherapy to your neck guided by lymph node mapping (lymphatic mapping) using a special X-ray called Single Photon Emission Computed Tomography (SPECT-CT) compared to the current standard treatment where radiotherapy is given to both sides of the neck.

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Hematologic Clinical Trials

A multiple myeloma clinical trial - MY13
Trial Code: MY.13 ǀ NCT06182774
Disease Site: Hematologic Clinical Trials

What is the purpose of this study?

One of the treatments for multiple myeloma is with three medicines, all continued indefinitely until they stop working, or side effects happen. Two are tablets, and the third is an injection. In this study, we are testing if the injection can be stopped after around 18 months of treatment with no change to how your multiple myeloma is being controlled.

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A primary central nervous system lymphoma clinical trial - IND244
Trial Code: IND244 ǀ NCT05998642
Disease Site: Hematologic Clinical Trials

What is the purpose of this study?

The purpose of this study is to find out if addition of a new oral drug to the usual treatment will lower the chance of your primary central nervous system lymphoma (PCNSL) growing or spreading.

 

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A hematology clinical trial - HD12
Trial Code: HD12 │ NCT04685616
Disease Site: Hematologic Clinical Trials

What is the purpose of this study?

The purpose of this study is to compare the usual treatment for your Hodgkin lymphoma, which is a standard combination of four drugs, versus the standard combination with one drug of the combination replaced with a new drug that we hope will be more effective and cause you fewer side effects.

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A Hodgkin Lymphoma trial - HD11
Trial Code: HD.11 ǀ NCT05180097
Disease Site: Hematologic Clinical Trials

What is the purpose of this study?

The purpose of this study is to see the effects on you and your lymphoma of a new drug combination compared to other drugs that are currently used in standard treatment.

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A hematology clinical trial - CLC3
Trial Code: CLC3 ǀ NCT04269902
Disease Site: Hematologic Clinical Trials

What is the purpose of this study?

The purpose of this trial is to find out if people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) will live longer and have a better quality of life if they start treatment earlier. Some people do not have major symptoms when they are diagnosed with CLL or SLL. Treatment is often started when they show symptoms such as fever, anemia, or night sweats. Studies have shown that early treatment using older chemotherapy drugs doesn’t improve outcomes compared to later treatment.

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A hematology clinical trial - ALC7
Trial Code: ALC.7 (MYELOMATCH) ǀ NCT05564390
Disease Site: Hematologic Clinical Trials
esting for Biomarkers to Match People with Myeloid Cancer to myeloMATCH Clinical Trials for Treatment

What is the purpose of this study?

This trial is the first step in joining a large research study called myeloMATCH.

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A hematology clinical trial - AL6
Trial Code: AL.6 (MM1YA-CTG01) ǀ NCT05554393
Disease Site: Hematologic Clinical Trials

What is the purpose of this study?

The purpose of this study is to compare the usual treatment for acute myeloid leukemia (AML) with two different combinations of treatment.

This trial is part of a larger research study called myeloMATCH - https://www.ctg.queensu.ca/patients/hematology-clinical-trial-alc7

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Lung Clinical Trials

A small cell lung cancer clinical trial - BRC8
Trial Code: BRC.8 ǀ NCT04155034
Disease Site: Lung Clinical Trials

What is the purpose of this study?

The purpose of this study is to compare the use of magnetic resonance imaging (MRI) surveillance combined with prophylactic cranial irradiation (PCI) to MRI surveillance alone in treating your lung cancer that can sometimes spread to the brain.

Why is this study important?

MRI scans are used to monitor the possible spread of the cancer with an MRI machine over time. PCI is radiation therapy that is delivered to the brain in hopes of preventing spread of cancer into the brain.

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Melanoma Clinical Trials

A melanoma clinical trial - MEC6
Trial Code: MEC6 | NCT05111574
Disease Site: Melanoma Clinical Trials

What is the purpose of this study?

The purpose of this study is to compare the effects on you and your mucosal melanoma of a new drug with the usual treatment compared to a placebo with the usual treatment.

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Sarcoma Clinical Trials

A sarcoma study - SR7
Trial Code: SR.7 | NCT04031677
Disease Site: Sarcoma Clinical Trials

What is the purpose of this study?

The purpose of this study is to compare the effects of receiving chemotherapy before surgery on you and your sarcoma compared to surgery alone.

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Symptom Control Clinical Trials

A radiation therapy for symptom control cancer clinical trial - SC29
Trial Code: SC.29 ǀ NCT06391242
Disease Site: Symptom Control Clinical Trials

What is the purpose of this study?

This study is being done to answer the following question: For bone cancer, is Stereotactic Body Radiation Therapy (SBRT) better for pain relief than the standard conventional radiation therapy (CRT)?

SRBT is high dose radiation therapy that targets painful areas of cancer, while keeping the radiation away from the healthy tissue around the cancer. CRT is radiation therapy that is directed at the painful area but can negatively affect unaffected areas.

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A supportive care clinical trial - SC28
Trial Code: SC.28 ǀ NCT05470010
Disease Site: Symptom Control Clinical Trials

What is the purpose of this study?

The purpose of this study is to test if a mindfulness program (Mindfulness Based Cancer Survivorship (MBCS) Journey) delivered through a mobile smartphone application (Am Mindfulness) can reduce ongoing psychosocial symptoms such as stress, anxiety, depression, fatigue, and fear of cancer recurrence or progression that are often experienced by survivors.

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