CCTG has opened the anticipated international brain cancer study CCTG CE9 (LUMOS2) - joining forces with the Australian Cooperative Trials Group for Neuro-Oncology (COGNO) to make enrollment accessible to Canadian patients.
Botensilimab + Balstilimab vs Best Supportive Care as Therapy in Chemo-refractory, Unresectable, Colorectal Adenocarcinoma: The BATTMAN Trial
STRIDE (durvalumab + tremelimumab) with Lenvatinib vs STRIDE Alone in Patients with Unresectable Hepatocellular Carcinoma (SLIDE-HCC)
The CCTG ES3 NEEDS international esophageal cancer clinical trial is now opened in Canada. The study is investigating whether delaying surgery for patients with squamous cell carcinoma of the esophagus is as good as the current treatment.
Venetoclax and HMA-based Therapies for the Treatment of Older and Unfit Adults with Newly Diagnosed FLT3-mutated AML: A myeloMATCH Treatment Trial
Phase 2 Trial of ASTX727 and Venetoclax Compared with ASTX727, Venetoclax, and Enasidenib for Newly Diagnosed Older Adults with IDH2 Mutant AML - A myeloMATCH Substudy
Eradicating MRD in Patients with AML prior to Stem Cell Transplant (ERASE)
LUNA-2: LND101 in Unresectable Non-Small Cell Lung Cancer: A Randomized Phase II Trial
VIGOR: Vorasidenib as Maintenance Treatment after First-line Chemoradiotherapy in IDH-mutant Grade 2 or 3 Astrocytoma
RAINBO-ORANGE: Treatment of Endometrial Cancer Based On Molecular Features
The myeloMATCH North American platform study is now open in Canada and comprises a series of clinical trials to treat patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).
MAC30 has recently opened in Canada and will compare two commonly used treatment choices for premenopausal women with ER-positive/HER2-negative breast cancer and a low to intermediate risk of recurrence. Researchers are testing the addition of chemotherapy to ovarian function suppression plus hormonal therapy versus ovarian function suppression plus hormonal therapy alone. Both these approaches are used across North America, and it is not clear as to whether chemotherapy is needed in this population.
The IND.227: A Phase II/III Randomized Study of Pembrolizumab in Patients with Advanced Malignant Pleural Mesothelioma has permanently trial closed.
October is breast cancer awareness month and in recognition we have a new video interview with our CCTG Breast Cancer Patient Representative Michelle Audoin.
"The research investments in cancer clinical trials and progressive treatment options I have seen in recent years give me hope for the future. Which is why it’s important for me to bring my voice to the development of cancer clinical trials. I want to support inclusive trial enrollment, thereby improving the generalizability of results for diverse communities," says Michelle.
Joseph L. Pater, O.C. Kingston, Ontario
MAC23 (Oral, Plenary) - https://www.redjournal.org/article/S0360-3016(24)00764-8/fulltext
A Randomized Trial of Hypofractionated Post-Mastectomy Radiation Therapy (PMRT) in Women with Breast Reconstruction (RT CHARM, Alliance A221505)
The CCTG HN10 (EVADER) results were presented at the American Society for Radiation Oncology (ASTRO) 2024 Annual Meeting in Washington DC. The late breaking results concluded that radiotherapy to some of the lymph node areas can be safely excluded to decrease side effects without compromising tumour control.
Sexual Health and Quality of Life in Patients With Low-Risk Early-Stage Cervical Cancer: Results From GCIG/CCTG CX.5/SHAPE Trial Comparing Simple Versus Radical Hysterectomy
