CCTG has opened the anticipated international brain cancer study CCTG CE9 (LUMOS2) - joining forces with the Australian Cooperative Trials Group for Neuro-Oncology (COGNO) to make enrollment accessible to Canadian patients.
Botensilimab + Balstilimab vs Best Supportive Care as Therapy in Chemo-refractory, Unresectable, Colorectal Adenocarcinoma: The BATTMAN Trial
STRIDE (durvalumab + tremelimumab) with Lenvatinib vs STRIDE Alone in Patients with Unresectable Hepatocellular Carcinoma (SLIDE-HCC)
The CCTG ES3 NEEDS international esophageal cancer clinical trial is now opened in Canada. The study is investigating whether delaying surgery for patients with squamous cell carcinoma of the esophagus is as good as the current treatment.
Venetoclax and HMA-based Therapies for the Treatment of Older and Unfit Adults with Newly Diagnosed FLT3-mutated AML: A myeloMATCH Treatment Trial
Eradicating MRD in Patients with AML prior to Stem Cell Transplant (ERASE)
LUNA-2: LND101 in Unresectable Non-Small Cell Lung Cancer: A Randomized Phase II Trial
VIGOR: Vorasidenib as Maintenance Treatment after First-line Chemoradiotherapy in IDH-mutant Grade 2 or 3 Astrocytoma
RAINBO-ORANGE: Treatment of Endometrial Cancer Based On Molecular Features
Delayed Reduced Volume and Dose Elective Ratiotherapy (REVERT) in Patients with HNSCC
Joseph L. Pater, O.C. Kingston, Ontario
MAC23 (Oral, Plenary) - https://www.redjournal.org/article/S0360-3016(24)00764-8/fulltext
A Randomized Trial of Hypofractionated Post-Mastectomy Radiation Therapy (PMRT) in Women with Breast Reconstruction (RT CHARM, Alliance A221505)
The CCTG HN10 (EVADER) results were presented at the American Society for Radiation Oncology (ASTRO) 2024 Annual Meeting in Washington DC. The late breaking results concluded that radiotherapy to some of the lymph node areas can be safely excluded to decrease side effects without compromising tumour control.
Sexual Health and Quality of Life in Patients With Low-Risk Early-Stage Cervical Cancer: Results From GCIG/CCTG CX.5/SHAPE Trial Comparing Simple Versus Radical Hysterectomy
The HE1 clinical trial has permanently closed, the study confirmed that the quality-of-life benefits of palliative radiation therapy for symptomatic hepatocellular carcinoma and liver metastases. This trial no longer requires action, including the cessation of all patient follow-up for trial purposes, completion of Case Report Forms and obtaining of annual REB re-approvals.
Primary Publication
The CCTG CO32 clinical trial testing chemotherapy alone versus chemotherapy plus radiotherapy prior to limited surgery for early rectal cancer has initiate in Canada.
The Canadian Cancer Trials Group (CCTG) is currently seeking an outstanding and visionary cancer trialist for the position of Senior Investigator (SI) and Chair in Clinical Trials at Queens University.
