CCTG has opened the anticipated international brain cancer study CCTG CE9 (LUMOS2) - joining forces with the Australian Cooperative Trials Group for Neuro-Oncology (COGNO) to make enrollment accessible to Canadian patients.
Venetoclax and HMA-based Therapies for the Treatment of Older and Unfit Adults with Newly Diagnosed FLT3-mutated AML: A myeloMATCH Treatment Trial
VIGOR: Vorasidenib as Maintenance Treatment after First-line Chemoradiotherapy in IDH-mutant Grade 2 or 3 Astrocytoma
Botensilimab + Balstilimab vs Best Supportive Care as Therapy in Chemo-refractory, Unresectable, Colorectal Adenocarcinoma: The BATTMAN Trial
Autologous Stem Cell Transplant in Peripheral T Cell Lymphoma that Achieved a First Complete Remission (CR1) Following Induction Therapy (PTCL-STAT)
The CCTG ES3 NEEDS international esophageal cancer clinical trial is now opened in Canada. The study is investigating whether delaying surgery for patients with squamous cell carcinoma of the esophagus is as good as the current treatment.
Phase 2 Trial of ASTX727 and Venetoclax Compared with ASTX727, Venetoclax, and Enasidenib for Newly Diagnosed Older Adults with IDH2 Mutant AML - A myeloMATCH Substudy
Eradicating MRD in Patients with AML prior to Stem Cell Transplant (ERASE)
LUNA-2: LND101 in Unresectable Non-Small Cell Lung Cancer: A Randomized Phase II Trial
RAINBO-ORANGE: Treatment of Endometrial Cancer Based On Molecular Features
Delayed Reduced Volume and Dose Elective Radiotherapy (REVERT) in Patients with HNSCC
No Chemotherapy in Intermediate-risk HR + HER2- Early Breast Cancer Treated with Ribociclib (NoLEEta)
We are pleased to inform you that the Canadian Cancer Trials Group (CCTG) is organizing our next Clinical Research Associate (CRA) Lunch and Learn training program, to be held on Wednesday, May 13th, 2026, at 12 pm ET on the topic: NCTN Clinical Trial Support Unit (CTSU) OPEN System and upcoming changes
Permanent trial closure for MAC4 (IBCSG 24-02): A Phase III Trial Evaluating the Role of Ovarian Function Suppression and the Role of Exemestane as Adjuvant Therapies for Premenopausal Women With Endocrine Responsive Breast Cancer and MAC5 (IBCSG 25-02): A Phase III Trial Evaluating the Role of Exemestane Plus GnRH Analogue as Adjuvant Therapy for Premenopausal Women with Endocrine Responsive Breast Cancer
In early November, our CCTG Patient Representative Committee Chair, Judy Needham was invited to Brussels, Belgium, as a Breast International Group (BIG) Patient Partner. During her visit she attended BIG Executive Board Meetings, Patient Partner Meetings, and was privileged to be invited to a luncheon with the Queen Mathilde of Belgium who is the honorary President of BIG.
With sadness CCTG acknowledges the passing of one of our influential international research partners, Mr Russell Conley. Russell was Chief Executive Officer of the Australasian Gastro-Intestinal Trials Group (AGITG) and the GI Cancer Institute for 22 years. He was instrumental in all of the growing list of CCTG and AGITG GI collaborations, including CO.17, CO.20, CO.23, CO.29, NE.2 as well as the Commonwealth Neuroendocrine Tumour Research Collaboration (CommNETs).
The recently opened CCTG PR25 clinical trial uses a personalized medicine approach to investigate and evaluate markers to determine which metastatic prostate cancer patients would benefit from treatment with carboplatin a drug used in other cancers but not routinely used in prostate cancer.
