Wednesday, September 23, 2026 Association of tumor mutational burden and tumor-infiltrating lymphocytes with second primary cancer after complete resection of non-small cell lung cancer The risk of developing second primary cancers (SPC) after complete surgical resection of non-small cell lung cancer (NSCLC) has been estimated at 1-2% per patient-year. Researchers investigated whether tumor genomic instability, assessed by tumor mutational burden (TMB), and host immune response, assessed by tumor-infiltrating lymphocytes (TILs), were associated with the development of SPC. Gauthier M-P, Karimi M, Michiels S, Seymour L, Brambilla E, Le-Chevalier T, Soria J-C, Kratzke R, Graziano SL, Govindan R, Tsao M-S, Shepherd FA. Association of tumor mutational burden and tumor-infiltrating lymphocytes with second primary cancer after complete resection of non-small cell lung cancer. Frontiers in Oncology Volume 16: 1773288. 2026.https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1773288
