Wednesday, October 08, 2025 CRC6 secondary analysis : Sex differences in chemotherapy completion, toxicities, and survival in colon cancer Cheng E, Shi Q, Shields AF, Xue X, Rohan TE, Kuang C, Shergill AP, Ma C, Couture F, Kuebler JP, Kumar P, Tan B, Krishnamurthi SS, Ng K, O'Reilly EM, Brown JC, Meyerhardt JA. Sex differences in chemotherapy completion, toxicities, and survival in colon cancer: an analysis of 2201 patients from CALGB/SWOG 80702 (alliance) (ONLINE). JNCI: Journal of the National Cancer Institute 2025. Completing adjuvant chemotherapy and reducing toxicities are critical tenets to maximize survival after colon cancer diagnosis. Sex, as a biological variable, may impact colon cancer chemotherapy completion, toxicities, and survival differently.