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Publication: BR34, CO26, IND226 and PA7 pooled analysis

Publication: Pooled Analysis BR34, CO26, IND226 and PA7

Effects of serotonergic drugs on immune checkpoint inhibitor response: a pooled analysis of individual patient data from four Canadian Cancer Trials Group (CCTG) trials BR34, CO26, I226 and PA7

Immune checkpoint inhibitors (ICIs) are used to treat various cancers. Serotonin receptors are expressed by immune cells. In preclinical models, serotonergic drugs affect T-cell cytokine production, proliferation and apoptosis. Interactions between clinical serotonergic drug use and dual ICI treatment remain unknown.
 
Coschi CH, Ding K, Tu D, O’Callaghan C, Leighl NB, Vera-Badillo F, Juergens RA, Hao D, Seymour L, Renouf DJ, Chen E, Fung AS, Gaudreau P-O. Effects of serotonergic drugs on immune checkpoint inhibitor response: a pooled analysis of individual patient data from four Canadian Cancer Trials Group (CCTG) trials. Immunotherapy 17: 1085-1097. 2025.