CCTG at ASCO 2022

American Society of Clinical Oncology General Meeting 2022

June 3-7, 2022 – McCormick Place, Chicago

CCTG MA32
Metformin, placebo, and endocrine therapy discontinuation among participants in a randomized double-blind trial of metformin versus placebo in hormone receptor–positive early-stage breast cancer (CCTG MA32)
Session Type: Poster Session
Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 526)
Authors: Dawn L. Hershman, Bingshu E. Chen, Wendy R. Parulekar, Julie Lemieux, Jennifer A. Ligibel, Karen A. Gelmon, Timothy Joseph Whelan, Pamela Jean GoodwinAbstract link to be confirmed.

Abstract link: https://meetings.asco.org/abstracts-presentations/210746

CCTG MA37
Impact of body mass index on treatment and outcomes in patients with early hormone receptor-positive breast cancer receiving endocrine therapy with or without palbociclib in the PALLAS trial
Session Type: Poster Discussion Session
Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 518)
Authors: Georg Pfeiler, Dominik Hlauschek, Erica L. Mayer, Christine Deutschmann, Stephanie Kacerovsky-Strobl, Miguel Martin, Jane Lowe Meisel, Nicholas Zdenkowski, Sibylle Loibl, Marija Balic, Haeseong Park, Aleix Prat, Claudine Isaacs, Jana Machacek-Link, Celine Schurmans, Kathy Puyana Theall, Christian Fesl, Amylou C. Dueck, Angela DeMichele, Michael Gnant

Abstract link: https://meetings.asco.org/abstracts-presentations/209134

CCTG MAC28
NRG-BR007: A phase III trial evaluating de-escalation of breast radiation (DEBRA) following breast-conserving surgery (BCS) of stage 1, hormone receptor+, HER2-, RS ≤18 breast cancer
Session Type: Poster Session
Citation: J Clin Oncol 40, 2022 (suppl 16; abstr TPS613)
Authors: Julia R. White, Stewart J. Anderson, Eleanor Elizabeth Harris, Eleftherios P. Mamounas, Daniel G. Stover, Patricia A. Ganz, Reshma Jagsi, Reena S. Cecchini, Carmen Bergom, Valerie Theberge, Mahmoud El-Tamer, Richard C. Zellars, Dean Alden Shumway, Guang-Pei Chen, Thomas B. Julian, Norman Wolmark

Abstract link: https://meetings.asco.org/abstracts-presentations/213519

CCTG MAC22
Adjusting the TMIST study design to accommodate slower than expected accrual: ECOG-ACRIN EA1151
Session Type: Poster Session

Citation: J Clin Oncol 40, 2022 (suppl 16; abstr TPS10614)
Authors: Etta Pisano, Constantine Gatsonis, Mitchell D. Schnall, Martin Yaffe, Melissa A. Troester, Ilana F. Gareen, Laura C. Collins, Amarinthia Curtis, Elodia B Cole, Jean Cormack, Jon Steingrimsson, Ruth C Carlos, Kathy Miller, Christopher Comstock

Abstract link: https://meetings.asco.org/abstracts-presentations/213412

CCTG MAC11
Vitamin D insufficiency as a peripheral neuropathy risk factor in white and black patients in SWOG 0221
Session Type: Poster Discussion Session
Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 12023)
Authors: Ciao-Sin Chelsea Chen, Gary Zirpoli, Susan McCann, William E. Barlow, George Thomas Budd, Lajos Pusztai, Gabriel N. Hortobagyi, Andrew K. Godwin, Alastair Mark Thompson, Christine B. Ambrosone, Kathleen A Stringer, Daniel Louis Hertz

Abstract link: https://meetings.asco.org/abstracts-presentations/209887


CCTG CO26
Effects of liver metastases on efficacy of immune checkpoint blockade in treatment refractory, metastatic colorectal cancer (CRC): CCTG CO.26
Session Type: Poster Session
Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 3600)
Authors: Eric Xueyu Chen, Jonathan M. Loree, Dongsheng Tu, Christopher J. O'Callaghan, Hagen Fritz Kennecke, Derek J. Jonker, Ahmad Chaudhary, Bruce Colwell, Mohammed Harb, Nathalie Aucoin, Felix Couture, Setareh Samimi, Petr Kavan, Francine Aubin, Benoit Samson, John R. Goffin, Scott Berry, Tahir Abbas, Sheryl L. Koski, Alice Chia-chi Wei

Abstract link: https://meetings.asco.org/abstracts-presentations/208510

CCTG CO26
Impact of consensus molecular subtyping (CMS) on survival in the CO.26 trial of durvalumab plus tremelimumab versus best supportive care (BSC) in metastatic colorectal cancer (mCRC)
Session Type: Poster Session
Session Title: Gastrointestinal Cancer – Colorectal and Anal
Track: Gastrointestinal Cancer – Colorectal and Anal
Citation: https://meetings.asco.org/abstracts-presentations/208452
Authors: Jonathan M. Loree, James T. Topham, Hagen Fritz Kennecke, Harriet Feilotter, Young S Lee, Shakeel Virk, Scott Kopetz, Dzifa Yawa Duose, Ganiraju C. Manyam, Jeffrey S Morris, Dipen M. Maru, Daniel Renouf, Derek J. Jonker, Dongsheng Tu, Christopher J. O'Callaghan, Eric Xueyu Chen

Abstract link: https://meetings.asco.org/abstracts-presentations/208452


CCTG CRC5
Gene expression of vitamin D (VitD) pathway markers and survival in patients (Pts) with metastatic colorectal cancer (mCRC): CALGB/SWOG 80405 (Alliance)
Session Type: Poster Session
Session Title: Gastrointestinal Cancer – Colorectal and Anal
Track: Gastrointestinal Cancer – Colorectal and Anal
Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 3553)
Authors: Christine G Kohn, Fang-Shu Ou, Chao Ma, Nicholas B Larson, Tyler J. Zemla, Chen Yuan, Donna Niedzwiecki, Bruce W. Hollis, Andrew B. Nixon, Heinz-Josef Lenz, Charles David Blanke, Richard M. Goldberg, Robert J. Mayer, Alan P. Venook, Eileen Mary O'Reilly, Jeffrey A. Meyerhardt, Kimmie Ng

Abstract link: https://meetings.asco.org/abstracts-presentations/208514


CCTG CRC5
Predictive value of MAOB gene expression for targeted therapy in patients (pts) with metastatic colorectal cancer (mCRC) enrolled in CALGB (Alliance)/SWOG 80405
Session Type: Poster Session
Session Title: Gastrointestinal Cancer – Colorectal and Anal
Track: Gastrointestinal Cancer – Colorectal and Anal
Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 3580)
Authors: Wu Zhang, Joshua Millstein, Yan Yang, Fang-Shu Ou, Federico Innocenti, Hiroyuki Arai, Shivani Soni, Shannon M. Mumenthaler, Sandra Algaze, Priya Jayachandran, Monica M. Bertagnolli, Dustin A. Deming, Donna Niedzwiecki, Richard M. Goldberg, Robert J. Mayer, Charles David Blanke, Alan P. Venook, Omar Kabbarah, Francesca Battaglin, Heinz-Josef Lenz

Abstract link: https://meetings.asco.org/abstracts-presentations/208442

CCTG CRC.2
Effect of primary tumor sidedness on the association of tumor-infiltrating lymphocytes with survival of patients with stage III colon cancer (NCCTG N0147) [alliance]
Session Type: Poster Session
Session Title: Gastrointestinal Cancer – Colorectal and Anal
Track: Gastrointestinal Cancer – Colorectal and Anal
Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 3525)
Authors: Bahar Saberzadeh Ardestani, Nathan R. Foster, Hee Eun Lee, Qian Shi, Steven R Alberts, Thomas C. Smyrk, Frank A. Sinicrope

Abstract link: https://meetings.asco.org/abstracts-presentations/208355

CCTG PR.21
A randomized phase II study of [177lu]lu-PSMA-617 verus docetaxel in patients with metastatic castration-resistant prostate cancer and PSMA-positive disease (NCT04663997)
Session Type: Poster Session
Session Title: Genitourinary Cancer – Prostate, Testicular, and Penile
Track: Genitourinary Cancer – Prostate, Testicular, and Penile
Subtrack: Genitourinary Cancer – Prostate, Testicular, and Penile
Citation: J Clin Oncol 40, 2022 (suppl 16; abstr TPS5110)
Authors: Kim N. Chi, Fred Saad, Wendy R. Parulekar, Urban Emmenegger, Sebastien J. Hotte, Frederic Pouliot, Glenn Bauman, Katherine A. Zukotynski, Stuart Peacock, Alexander William Wyatt, Jean-Mathieu Beauregard, Justin Lee, Carlos Uribe, Conor Dellar, Keyue Ding, Francois Benard

Abstract link: https://meetings.asco.org/abstracts-presentations/213296

CCTG BL.13
A randomized phase II trial assessing trimodality therapy with or without adjuvant durvalumab to treat patients with muscle-invasive bladder cancer (NCT03768570)
Session Type: Poster Session
Session Title: Genitourinary Cancer – Kidney and Bladder
Track: Genitourinary Cancer – Kidney and Bladder
Subtrack: Genitourinary Cancer – Kidney and Bladder
Citation: J Clin Oncol 40, 2022 (suppl 16; abstr TPS4619)
Authors: Wassim Kassouf, Simon J. Crabb, Ignacio Duran, Michael Donald Brundage, M. Neil Reaume, Alice Dragomir, Alexander William Wyatt, Francisco Emilio Vera Badillo, Himu Lukka, Tamim Niazi, Luis Souhami, Srikala S. Sridhar, Gareth Owen Griffiths, Doris Howell, Harriet Richardson, Marina Djurfeldt, Keyue Ding, Wendy R. Parulekar

Abstract link: https://meetings.asco.org/abstracts-presentations/213450

CCTG BLC.5
MAIN-CAV: Phase III randomized trial of maintenance cabozantinib and avelumab versus avelumab after first-line platinum-based chemotherapy in patients with metastatic urothelial cancer (mUC) (Alliance A032001)
Session Type: Poster Session
Session Title: Genitourinary Cancer – Kidney and Bladder
Track: Genitourinary Cancer – Kidney and Bladder
Citation: J Clin Oncol 40, 2022 (suppl 16; abstr TPS4607)
Authors: Shilpa Gupta, Karla V. Ballman, Matt D. Galsky, Michael J. Morris, Ronald C. Chen, Timothy A. Chan, Laurent Dercle, Yujia Wen, Srikala S. Sridhar, Aihua Edward Yen, Petros Grivas, Alan Tan, Shiva Baghaie, Jonathan E. Rosenberg

Abstract link: https://meetings.asco.org/abstracts-presentations/213289

BR.34
Effect of bone metastasis on outcomes in the CCTG BR.34 phase II randomized trial of dual immune checkpoint inhibitor (ICI) treatment with or without chemotherapy in high-risk, stage IVA/B NSCLC
Session Type: Poster Session
Session Title: Lung Cancer – Non-Small Cell Metastatic
Track: Lung Cancer
Subtrack: Lung Cancer
Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 9067)
Authors: Kim Leitzel, Suhail M. Ali, Keyue Ding, Natasha B. Leighl, Francisco Emilio Vera Badillo, Pierre-Olivier Gaudreau, Penelope Ann Bradbury, Glenwood D. Goss, Lois E. Shepherd, Luis Costa, Larry J Suva, Joseph J. Drabick, Patrick C. Ma, Monika Joshi, Hyma Vani Polimera, Allan Lipton


Abstract link: https://meetings.asco.org/abstracts-presentations/212914


CCTG BRC.6
Representativeness of patients enrolled in the Lung Cancer Master Protocol (Lung-MAP)
Session Type: Poster Session
Session Title: Health Services Research and Quality Improvement
Track: Health Services Research and Quality Improvement
Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 6543)
Authors: Riha Vaidya, Joseph M. Unger, Lu Qian, Katherine Minichiello, Roy S. Herbst, David R. Gandara, Joel W. Neal, Ticiana Leal, Jyoti D. Patel, Konstantin H. Dragnev, Saiama Naheed Waqar, Martin Joseph Edelman, Ellen V. Sigal, Stacey Adam, Shakun M. Malik, Charles David Blanke, Michael Leo LeBlanc, Karen Kelly, Mary Weber Redman

Abstract link: https://meetings.asco.org/abstracts-presentations/206721

CCTG BRC.6I
Dynamic changes in serum analyte levels associated with clinical outcome in squamous cell lung cancer trial SWOG Lung-MAP S1400I of nivolumab ± ipilimumab
Session Type: Poster Session
Session Title: Lung Cancer – Non-Small Cell Metastatic
Track: Lung Cancer
Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 9044)
Authors: Edgar Gonzalez-Kozlova, Hsin-Hui Huang, Mary Weber Redman, Roy S. Herbst, Scott N. Gettinger, Lyudmila Bazhenova, Hui Xie, Manishkumar Patel, Kai Nie, Jocelyn Harris, Kimberly Argueta, Ethan Cerami, Joyce Hong, Roshni Biswas, Stephen Van Nostrand, Karen Kelly, Radim Moravec, Diane Del Valle, Seunghee Kim-Schulze, Sacha Gnjatic

Abstract link: https://meetings.asco.org/abstracts-presentations/209307

CCTG BRC.6I
Multiomics profiling and association with molecular and immune features in association with benefits from immunotherapy for patients with previously treated stage IV or recurrent squamous cell lung cancer from the phase III SWOG LungMAP S1400I trial
Session Type: Poster Session
Session Title: Lung Cancer – Non-Small Cell Metastatic
Track: Lung Cancer
Citation: J Clin Oncol 40, 2022 (suppl 16; abstr 9046)
Authors: Edwin R. Parra, Dzifa Yawa Duose, Jiexin Zhang, Mary Weber Redman, Rossana Lazcano Segura, Mario L. Marques-Piubelli, Caddie Laberiano Fernandez, BaiLi Zhang, James Lindsay, Radim Moravec, Kasthuri Kannan, Rajyalakshmi Luthra, Gheath Alatrash, Roy S. Herbst, Ignacio Ivan Wistuba, Scott N. Gettinger, Lyudmila Bazhenova, J. Jack Lee, Jianjun Zhang, Cara L. Haymaker

Abstract link: https://meetings.asco.org/abstracts-presentations/212896