POSITIVE Progress report now available

CCTG MAC18: Pregnancy after breast cancer
Wednesday, February 28, 2018

"POSITIVE" (CCTG MAC18 / ALLIANCE A221405) is a unique trial which is collecting information prospectively on disease and pregnancy outcome after interrupting endocrine therapy in women with endocrine responsive early breast cancer who wish to have a baby. The lead group have received many inquiries about the progress and developments of the trial. With that in mind, they have provided the first "POSITIVE Progress" update. It contains information about the developments of the trial with input from the Study Team, Study Chairs, Investigators and Patients. The "POSITIVE Progress" will be issued every 6 months.

The "POSITIVE Progress" can be found on the International Breast Cancer Study Group (IBCSG) website and on the CCTG website here and for more information about the CCTG MAC18 study visit the trial website.


Young breast cancer patients often face the disease before having addressed their family planning: they may not have time to wait for 5-10 years of treatment completion before considering pregnancy.

The best available evidence suggests that pregnancy after breast cancer does not increase a woman’s risk of developing a recurrence from her breast cancer and is safe for the baby. However, the available information was collected retrospectively, and a controlled prospective study is needed to confirm these results.

The POSITIVE study evaluates the safety of interrupting endocrine therapy for young women with hormone-sensitive breast cancer who wish to become pregnant.  Women will be followed for 10 years after the inclusion in the study.

Study videos available

The International Breast Cancer Study Group (IBCSG) with the collaboration and financial support of the young patient group of Southern Switzerland “Anna dai Capelli Corti” has developed a video to promote awareness about the IBCSG 48-14/BIG 8-13 POSITIVE study. The goal is to inform the scientific and patient communities about the availability of a controlled clinical study for young women with endocrine-responsive early breast cancer who wish a baby and to sensitize the health providers about the aspects unique to this population such as fertility and pregnancy. The video sees the participation of two young breast cancer survivors, Dr. Olivia Pagani and Dr. Fedro Peccatori as breast cancer experts and POSITIVE study scientific co-chairs and Dr. Gabriella Bianchi, psycho-oncologist.