Canadian Cancer Trials Group Bulletins

Trial Management Group

CCTG BRC.5 closed to new patient registration

A Phase III Randomized Trial of Lobectomy Versus Sublobular Resection For Small, Peripheral Non-Small Cell Lung Cancer CALGB 140503/CCTG BRC.5

The BRC.5 trial (CALGB 140503) has met its accrual target and was officially closed to new patient registration as of 4:30 p.m. ET Monday, March 13, 2017. Please note that patients that have been registered to Step 1 on or before March 13, 2017 may continue to randomization (Step 2).

For more information please contact the study coordinator: Cathy Davidson

Primary Objective
To determine whether DFS after sublobar resection (segmentectomy or wedge) is non-inferior to that after lobectomy in patients with small peripheral NSCLC.

Secondary Objectives
  • To determine whether overall survival(after sublobar resection) is non-inferior to that after lobectomy;
  • to determine the rates of loco-regional and systemic recurrence (exclusive of second primaries) after lobar and sublobar resection;
  • to determine the difference between the two arms of the study in pulmonary function as determined by expiratory flow rates measured at 6 months post-operatively.