Canadian Cancer Trials Group Bulletins

General


JAMA Oncology Publication: SC.23 trial

Effect of Radiotherapy on Painful Bone Metastases A Secondary Analysis of the NCIC Clinical Trials Group Symptom Control Trial SC.23

How soon after radiotherapy for painful bone metastases can an improvement in quality of life be expected?

Findings:
In this secondary analysis of 238 patients from the NCIC Clinical Trials Group Symptom Control Trial SC.23, responders to radiotherapy had significantly greater improvement in pain, pain characteristics, functional interference, and psychosocial aspects at day 10 and significant improvement in most domains of the European Organisation for Research and Treatment of Cancer Quality of Life Bone Metastases Module and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 15 Palliative at day 42 compared with non-responders.
Meaning:
Quality of life and pain may improve as early as 10 days after radiotherapy; thus, a single 8-Gy dose of radiotherapy for painful bone metastases should be offered to all patients, even those with poor survival.

McDonald R, Ding K, Brundage M, Meyer RM, Nabid A, Chabot P, Coulombe G, Ahmed S, Kuk J, Dar AR, Mahmud A, Fairchild A, Wilson CF, Wu JSY, Dennis K, DeAngelis C, Wong RKS, Zhu L, Chan S, Chow E. Effect of Radiotherapy on Painful Bone Metastases: A Secondary Analysis of the NCIC Clinical Trials Group Symptom Control Trial SC.23 (ONLINE). JAMA Oncology 2017

http://jamanetwork.com/journals/jamaoncology/fullarticle/2601221