Canadian Cancer Trials Group Bulletins

General


Single-Study Centres and DSMC Summary Reports

Trial-specific DSMC Summary Reports are now posted on trial websites. Single-study centres participating on these trials should download these reports and submit them to their Research Ethics Boards if required by local policy.

Trials currently under the Canadian Cancer Trials Group's DSMC oversight include:

Canadian Cancer Trials Group BL.12
A Multicentre Randomized Phase II Trial Comparing Nab-Paclitaxel to Paclitaxel in Patients with Advanced Urothelial Cancer Progressing On or After a Platinum-Containing Regimen

Canadian Cancer Trials Group BR.31
A Phase III Prospective Double-Blind Placebo-Controlled Randomized Study of Adjuvant MEDI4736 in Completely Resected Non-Small Cell Lung Cancer

Canadian Cancer Trials Group CE.6
A Randomized Phase III Study of Temozolomide and Short-Course Radiation vs Short-Course Radiation Alone in the Treatment of Newly-Diagnosed Glioblastoma Multiforme in Elderly Patients

Canadian Cancer Trials Group CO.21
A Phase III Study of the Impact of a Physical Activity Program on Disease-Free Survival in Patients with High Risk Stage II or Stage III Colon Cancer: A Randomized Controlled Trial (Challenge)

Canadian Cancer Trials Group CO.23
A Phase III Randomized Study of BBI608 and Best Supportive Care versus Placebo and Best Supportive Care in Patients with Pretreated Advanced Colorectal Carcinoma

Canadian Cancer Trials Group CX.5
A Randomized Phase III Trial Comparing Radical Hysterectomy and Pelvic Node Dissection vs Simple Hysterectomy and Pelvic Node Dissection in Patients with Low-Risk Early Stage Cervical Cancer

Canadian Cancer Trials Group IND.209
A Randomized Phase II Study Of Reolysin? in Combination With Docetaxel and Prednisone or Docetaxel and Prednisone Alone in patients With Metastatic Castration Resistant Prostate Cancer

Canadian Cancer Trials Group IND.210
A Randomized Phase II Study of Reolysin? in Combination with FOLFOX6 and Bevacizumab or FOLFOX6 and Bevacizumab Alone in Patients with Metastatic Colorectal Cancer

Canadian Cancer Trials Group IND.211
A Randomized Phase II Study of Reolysin? in Patients With Previously Treated Advanced or Metastatic, Non Small Cell Lung Cancer Receiving Standard Salvage Therapy

Canadian Cancer Trials Group IND.213
A Randomized Phase II Study of Reolysin? For Patients Receiving Standard Weekly Paclitaxel Therapy as Therapy For Advanced/Metastatic Breast Cancer

Canadian Cancer Trials Group MA.17R
A Double Blind Re-Randomization to Letrozole or Placebo for Women Completing Five Years of Adjuvant Letrozole in the MA.17 Study

Canadian Cancer Trials Group MA.32
A Phase III Randomized Trial of Metformin versus Placebo on Recurrence and Survival in Early Stage Breast Cancer

Canadian Cancer Trials Group MAP.3
A Phase III Randomized Study of Exemestane Versus Placebo in Postmenopausal Women at Increased Risk of Developing Breast Cancer

Canadian Cancer Trials Group OV.21
Phase II/III Trial of Intraperitoneal (IP) Plus Intravenous (IV) Chemotherapy Versus IV Carboplatin Plus Paclitaxel in Patients with Epithelial Ovarian Cancer Optimally Debulked at Surgery Following Neoadjuvant Intravenous Chemotherapy

Canadian Cancer Trials Group PR.15
Randomized Phase II Feasibility Trial of Image-Guided External Beam Radiotherapy With or Without High Dose Rate Brachytherapy Boost in Men with Intermediate-Risk Prostate Cancer