Canadian Cancer Trials Group Bulletins


March is Colorectal Cancer Awareness Month

In recognition of Colorectal Cancer Awareness Month, the Canadian Cancer Society and Queen's University are highlighting the Canadian Cancer Trials Group's CHALLENGE trial (aka Canadian Cancer Trials Group CO.21).

CHALLENGE (Canadian Cancer Trials Group CO.21 -- A Phase III Study of the Impact of a Physical Activity Program on Disease-Free Survival in Patients with High Risk Stage II or Stage III Colon Cancer: A Randomized Controlled Trial (Challenge) -- is the first study of its kind to test if exercise can improve the cure rate of colon cancer and improve quality of life and physical function.

The trial is currently underway at 46 cancer centres in Canada and Australia and will soon expand to centres in the United States and Israel. Currently, there are about 300 patients enrolled and the trial aims to recruit 962 patients. The Canadian Cancer Society and Queen's University chose to highlight the trial to help increase awareness and interest in the trial in hopes of increasing centre participation and patient accrual.

"Our ultimate goal is to improve the survival and quality of life of patients with cancer," says trial co-chair Christopher Booth, associate professor at Queen's University. "As this will be the first and largest clinical trial to evaluate exercise in this setting, we also hope that the CHALLENGE trial will serve as a 'trailblazer' for other future studies of exercise and nutrition in patients with cancer."

Any centres and investigators interested in participating in the CHALLENGE trial should contact Patti O'Brien, Study Coordinator, at or 613-533-6430. Following is a link to the trial-specific website (please note that you may be required to provide your userid and PIN) ...

Links to the Canadian Cancer Society and Queen's University media releases about CHALLENGE are provided below: