Canadian Cancer Trials Group Bulletins

Group Administrators Office


Single-Study Centres and DSMC Summary Reports

Trial-specific DSMC Summary Reports are now posted on trial websites. Single-study centres participating on these trials should download these reports and submit them to their Research Ethics Boards if required by local policy.

The trials currently under the Canadian Cancer Trials Group's DSMC oversight include:

Canadian Cancer Trials Group BR.26
A Double-Blind Placebo Controlled Randomized Trial of PF-00299804 (PF-804) in Patients with Incurable Stage IIIB/IV Non-Small Cell Lung Cancer after Failure of Standard Therapy for Advanced or Metastatic Disease

Canadian Cancer Trials Group CE.6
A Randomized Phase III Study of Temozolomide and Short-Course Radiation vs Short-Course Radiation Alone in the Treatment of Newly-Diagnosed Glioblastoma Multiforme in Elderly Patients

Canadian Cancer Trials Group CO.21
A Phase III Study of the Impact of a Physical Activity Program on Disease-Free Survival in Patients with High Risk Stage II or Stage III Colon Cancer: A Randomized Controlled Trial (Challenge)

Canadian Cancer Trials Group CO.23
A Phase III Randomized Study of BBI608 and Best Supportive Care versus Placebo and Best Supportive Care in Patients with Pretreated Advanced Colorectal Carcinoma

Canadian Cancer Trials Group CX.5
A Randomized Phase III Trial Comparing Radical Hysterectomy and Pelvic Node Dissection vs Simple Hysterectomy and Pelvic Node Dissection in Patients with Low-Risk Early Stage Cervical Cancer

Canadian Cancer Trials Group HN.6
A Phase III Study of Standard Fractionation Radiotherapy with Concurrent High-Dose Cisplatin versus Accelerated Fractionation Radiotherapy with Panitumumab in Patients with Locally-Advanced Stage III and IV Squamous Cell Carcinoma of the Head and Neck

Canadian Cancer Trials Group IND.209
A Randomized Phase II Study Of Reolysin® in Combination With Docetaxel and Prednisone or Docetaxel and Prednisone Alone in patients With Metastatic Castration Resistant Prostate Cancer

Canadian Cancer Trials Group IND.210
A Randomized Phase II Study of Reolysin in Combination with FOLFOX6 and Bevacizumab or FOLFOX6 and Bevacizumab Alone in Patients with Metastatic Colorectal Cancer

Canadian Cancer Trials Group IND.211
A Randomized Phase II Study of Reolysin in Patients With Previously Treated Advanced or Metastatic, Non Small Cell Lung Cancer Receiving Standard Salvage Therapy

Canadian Cancer Trials Group IND.213
A Randomized Phase II Study of Reolysin For Patients Receiving Standard Weekly Paclitaxel Therapy as Therapy For Advanced/Metastatic Breast Cancer

Canadian Cancer Trials Group MA.17R
A Double Blind Re-Randomization to Letrozole or Placebo for Women Completing Five Years of Adjuvant Letrozole in the MA.17 Study

Canadian Cancer Trials Group MA.20
A Phase III Study of Regional Radiation Therapy in Early Breast Cancer

Canadian Cancer Trials Group MA.21
A Phase III Adjuvant Trial of Sequenced EC + Filgrastim + Epoetin Alfa Followed by Paclitaxel Versus Sequenced AC Followed by Paclitaxel Versus CEF as Therapy for Premenopausal Women and Early Postmenopausal Women Who Have Had Potentially Curative Surgery for Node Positive or High Risk Node Negative Breast Cancer

Canadian Cancer Trials Group MA.32
A Phase III Randomized Trial of Metformin versus Placebo on Recurrence and Survival in Early Stage Breast Cancer

Canadian Cancer Trials Group MAP.3
A Phase III Randomized Study of Exemestane Versus Placebo in Postmenopausal Women at Increased Risk of Developing Breast Cancer

Canadian Cancer Trials Group OV.21
Phase II/III Trial of Intraperitoneal (IP) Plus Intravenous (IV) Chemotherapy Versus IV Carboplatin Plus Paclitaxel in Patients with Epithelial Ovarian Cancer Optimally Debulked at Surgery Following Neoadjuvant Intravenous Chemotherapy

Canadian Cancer Trials Group SC.23
A Randomized Phase III Double-Blind Study of Dexamethasone versus Placebo in the Prophylaxis of Radiation-Induced Pain Flare following Palliative Radiotherapy for Bone Metastases