American Society of Clinical Oncology Annual Meeting Monday, June 05, 2017 It has been another busy year for Canadian Cancer Trials Group at the American Society of Clinical Oncology Annual Meeting. This conference brings together oncology professionals from around the world to discuss state-of-the-art treatments, new therapies with the best minds in the field of cancer research. CCTG is well represented on this world stage with three recognition awards, fifteen poster presentations, and four oral abstracts. See below for more details. For more information on the event see the ASCO 2017 website or you can follow the conversation on our twitter account @CDNCancerTrial #ASCO17 Recognition Awards Fellow of the American Society of Clinical Oncology Frances A. Shepherd, MD, Princess Margaret Cancer Centre, University Health Network, Toronto International Women Who Conquer Cancer Mentorship Award Mary Gospodarowicz, MD, FRCR, FRCPC, University of Toronto, Princess Margaret Cancer Centre 2017 Career Development Award Scott V. Bratman, MD, PhD, Princess Margaret Cancer Centre Oral Abstract CCTG OV.18 / MRC ICON6 - Overall survival results of ICON6: A trial of chemotherapy and cediranib in relapsed ovarian cancer Session Title: Gynecologic Cancer Date: Friday, June 2 Session Type: Oral Abstract Session Time: 3:00 PM - 6:00 PM – Abstract presentation @ 5:00 PM Location: S406, Abstract #5506 Abstract Jonathan A. Ledermann, Andrew C. Embleton, Timothy Perren, Gordon C. Jayson, Gordon J. S. Rustin, Stanley B. Kaye, Hal W. Hirte, Amit M. Oza, Michelle Margaret Vaughan, Michael Friedlander, Antonio Gonzalez Martin, Elizabeth Clark, Babasola O Popoola, Laura Farrelly, Ann Marie Swart, Adrian Cook, Richard S. Kaplan, Mahesh K B Parmar CCTG CL.3/CALGB 10404 (Alliance) - A genetic risk-stratified, randomized phase 2 intergroup study of fludarabine/antibody combinations in symptomatic, untreated chronic lymphocytic leukemia: Results from Cancer and Leukemia Group B (CALGB) 10404 (Alliance) Session Title: Hematologic Malignancies – Lymphoma and Chronic Lymphocytic Leukemia Date: Saturday, June 3 Session Type: Oral Abstract Session - Abstract presentation @ 4:00 PM Time: 3:00 PM - 6:00 PM Location: S100bc, Abstract #7503 Amy S. Ruppert, John C. Byrd, Nyla A. Heerema, Mitchell Reed Smith, John E. Godwin, Stephen Couban, Todd A. Fehniger, Michael Thirman, Alese E. Halvorson, Martin S. Tallman, Frederick R. Appelbaum, Richard M. Stone, Sue Robinson, Julie E. Chang, Sumithra J. Mandrekar, Richard A. Larson Abstract CCTG MAC.13 / BIG 2-06 / NCCTG (Alliance) N063D- Updated results from the phase III ALTTO trial comparing one year of anti-HER2 therapy with lapatinib alone (L), trastuzumab alone (T), their sequence (T→L) or their combination (L+T) in the adjuvant treatment of HER2-positive early breast cancer Session Title: Breast Cancer – Local/Regional/Adjuvant Date: Monday, June 5 Session Type: Oral Abstract Session – Abstract presentation @ 10:09 AM Time: 9:45 AM to 12:45 PM Location: Hall D2; Abstract #502 Alvaro Moreno-Aspitia, Eileen McCormick Holmes, Christian Jackisch, Evandro De Azambuja, Frances M. Boyle, David W. Hillman, Larissa A. Korde, Debora Fumagalli, Miguel A. Izquierdo, Ann E. McCullough, Antonio C. Wolff, Kathleen I. Pritchard, Michael Untch, Istvan Lang, Binghe Xu, Ian E. Smith, Carlos H. Barrios, Richard D. Gelber, Jose Baselga, Martine J. Piccart-Gebhart Abstract CCTG MA.34 / BIG 4-11 - APHINITY trial (BIG 4-11): A randomized comparison of chemotherapy plus trastuzumab plus placebo versus chemotherapy plus trastuzumab plus pertuzumab as adjuvant therapy in patients with HER2-positive early breast cancer Session Title: Breast Cancer – Local/Regional/Adjuvant Date: Monday, June 5 Session Type: Oral Abstract Session – Abstract presentation @ 9:45 AM Time: 9:45 AM to 12:45 PM Location: Hall D2; Abstract #LBA500 Gunter Von Minckwitz, Marion Jennifer Procter, Evandro De Azambuja, Dimitrios Zardavas, Adam Knott, Giuseppe Viale, Thomas M. Suter, Amal Arahmani, Nathalie Rouchet, Emma Clark, Mark Benyunes, Istvan Lang, Christelle Levy, Denise A. Yardley, Jose Bines, Richard D. Gelber, Martine J. Piccart-Gebhart, Jose Baselga Abstract CCTG MEC.3/E1609 - A phase III randomized study of adjuvant ipilimumab (3 or 10 mg/kg) versus high-dose interferon alfa-2b for resected high-risk melanoma: Preliminary safety and efficacy of the ipilimumab arms Session Title: Melanoma/Skin Cancers Date: Sunday, June 4 Session Type: Oral Abstract Session - Abstract presentation @ 8:00 AM Time: 8:00 AM to 11:00 AM Location: Arie Crown Theater, Abstract #9500 Ahmad A. Tarhini, Sandra J. Lee, F. Stephen Hodi, Uma N. M. Rao, Gary I Cohen, Omid Hamid, Laura Fulper Hutchins, Jeffrey Alan Sosman, Harriet M. Kluger, Vernon K. Sondak, Henry B. Koon, Donald P. Lawrence, Kari Lynn Kendra, David R. Minor, Carrie B. Lee, Mark R Albertini, Lawrence E. Flaherty, Teresa M. Petrella, John M. Kirkwood Abstract CCTG EN.7 / (DCGOG PORTEC-3) - Final results of the international randomized PORTEC-3 trial of adjuvant chemotherapy and radiation therapy (RT) versus RT alone for women with high-risk endometrial cancer. Session Title: Gynecologic Cancer Date: Friday, June 2 Session Type: Oral Abstract Session Time: 3:00 PM - 6:00 PM – Abstract presentation @ 5:00 PM Location: S406, Abstract #5502 Stephanie M. De Boer, Melanie E. Powell, Linda R. Mileshkin, Dionyssios Katsaros, Paul Bessette, Christine Haie-Meder, Petronella B Ottevanger, Jonathan A. Ledermann, Pearly Khaw, Alessandro Colombo, Anthony W. Fyles, Marie-Helene Baron, Henry C. Kitchener, Hans Nijman, Roy F.P.M. Kruitwagen, Ina M. Jurgenliemk-Schulz, Remi A. Nout, Vincent T.H.B.M. Smit, Hein Putter, Carien L. Creutzberg Abstract Poster Session CCTG - Evaluation of stored liquid biopsies for molecular profiling in patients with non-small cell lung cancer Session Title: Lung Cancer – Non-Small Cell Metastatic Date: Saturday, June 3 Session Type: Poster Session Time: 8:00 AM to 11:30 AM Location: Hall A, Abstract #9024; Poster Board #350 Abstract Penelope Ann Bradbury, Keyue Ding, Peter Michael Ellis, Lesley Seymour, Frank De Kievit, Greg Jones, Clive D. Morris, Emma Green, Glenwood D. Goss, Ming Sound Tsao, Frances A. Shepherd Cetuximab clearance and survival in patients with metastatic colorectal cancer Session Title: Gastrointestinal (Colorectal) Cancer Date: Saturday, June 3 Session Type: Poster Session Time: 8:00 AM to 11:30 AM Location: Hall A, Abstract #3600; Poster Board #223 Abstract: Di Maria Jiang, Hao-Wen Sim, Lillian L. Siu, Jeremy David Shapiro, Geoffrey Liu, Timothy Jay Price, Derek J. Jonker, Christos Stelios Karapetis, Andrew Strickland, Wenjiang Zhang, Mark Jeffery, Dongsheng Tu, Siobhan Ng, Sabe S. Sabesan, Jenny Shannon, Amanda Rose Townsend, Eric Morgen, Wei Xu, Christopher J. O'Callaghan, Eric Xueyu Chen CCTG CO.17/CO.20 - Age as a predictive and prognostic factor for targeted therapy treatment in metastatic chemorefractory colorectal cancer: An analysis of NCIC CTG CO.17 and CO.20. Session Title: Gastrointestinal (Colorectal) Cancer Date: Saturday, June 3 Session Type: Poster Session Time: 8:00 AM to 11:30 AM Location: Hall A, Abstract #3555; Poster Board #178 Abstract Connor Wells, Lillian L. Siu, Jeremy David Shapiro, Dongsheng Tu, Derek J. Jonker, Christos Stelios Karapetis, John Simes, Geoffrey Liu, Timothy Jay Price, Niall C. Tebbutt, Christopher J. O'Callaghan CCTG CO.26A phase II randomized study of - durvalumab plus tremelimumab and best supportive care (BSC) vs BSC alone in patients with advanced colorectal carcinoma refractory to standard therapies Session Title: Gastrointestinal (Colorectal) Cancer Date: Saturday, June 3 Session Type: Poster Session Time: 8:00 AM - 11:30 AM Location: Hall A, Abstract #TPS3621; Poster Board #242b Eric Xueyu Chen, Derek J. Jonker, Hagen F. Kennecke, Sheryl L. Koski, Alice Chia-chi Wei, Nadine M Magoski, Dongsheng Tu, Christopher J. O'Callaghan Abstract CCTG GA.3 / AGO315OG - Integrate II: A - randomised phase 3 double-blind placebo-controlled study of regorafenib in refractory advanced gastro-oesophageal cancer - An international study organized by the Australasian Gastrointestinal Trials Group Session Title: Gastrointestinal (Noncolorectal) Cancer Date: Saturday, June 3 Session Type: Poster Session Time: 8:00 AM to 11:30 AM Location: Hall A, Abstract #TPS4136; Poster Board #125b Katrin Marie Sjoquist, Nick Pavlakis, Andrew James Martin, Eric Tsobanis, Sonia Yip, Yung-Jue Bang, Thierry Alcindor, Christopher J. O'Callaghan, Kohei Shitara, Tanios S. Bekaii-Saab, Axel Grothey, Li-Tzong Chen, John Simes, John Raymond Zalcberg, David Goldstein Abstract CCTG CRC.2 / NCCTG N0147 (Alliance) - Analysis of serum vitamin D levels and prognosis in stage III colon carcinoma patients treated with adjuvant FOLFOX+/- cetuximab chemotherapy Session Title: Gastrointestinal (Colorectal) Cancer Date: Saturday, June 3 Session Type: Poster Session Time: 8:00 AM - 11:30 AM Location: Hall A, Abstract #3516; Poster Board #139 Session Type: Poster Discussion Session – Poster Discussion @ 1:33 PM Time: 1:15 PM - 2:30 PM Location: Arie Crown Theater Frank A. Sinicrope, Qian Shi, Thomas C. Smyrk, Richard M. Goldberg, Erica N Heying, Steven J. Cohen, Sharlene Gill, Morton S. Kahlenberg, Suresh Nair, Anthony Frank Shields, Daniel J. Sargent, Balkrishna N. Jahagirdar, Michael N. Pollak, Steven R. Alberts Abstract Association of immune markers and Immunoscore with survival of stage III colon carcinoma patients treated with adjuvant FOLFOX Session Title: Gastrointestinal (Colorectal) Cancer Date: Saturday, June 3 Session Type: Poster Session Time: 8:00 AM - 11:30 AM Location: Hall A, Abstract #3579; Poster Board #202 Frank A. Sinicrope, Qian Shi, Fabienne Hermitte, Erica N Heying, Al Bowen Benson, Sharlene Gill, Richard M. Goldberg, Morton S. Kahlenberg, Suresh Nair, Anthony Frank Shields, Daniel J. Sargent, Jerome Galon, Steven R. Alberts Abstract Genetic correlates of therapeutic toxicities of stage III colon carcinoma patients treated with adjuvant FOLFOX+/-cetuximab Session Title: Gastrointestinal (Colorectal) Cancer Date: Saturday, June 3 Session Type: Poster Session Time: 8:00 AM - 11:30 AM Location: Hall A, Abstract #3604; Poster Board #227 Polly A. Newcomb, Wei Sun, Xinwei Hua, Barbara L. Banbury, Amanda I. Phipps, Jonathan Kocarnik, Tabitha A. Harrison, Qian Shi, Frank A. Sinicrope, Stephen N. Thibodeau, Emily Chan, Sharlene Gill, Richard M. Goldberg, Morton S. Kahlenberg, Suresh Nair, Anthony Frank Shields, Balkrishna N. Jahagirdar, Ulrike Peters, Steven R. Alberts, Andrew T. Chan Abstract CCTG PA.7- A randomized phase II study of gemcitabine and nab-paclitaxel vs. gemcitabine, nab-paclitaxel, - durvalumab, and tremelimumab as 1st line therapy in metastatic pancreatic ductal adenocarcinoma Session Title: Gastrointestinal (Noncolorectal) Cancer Date: Saturday, June 3 Session Type: Poster Session Time: 8:00 AM - 11:30 AM Location: Hall A, Abstract #TPS4149; Poster Board #132a Daniel John Renouf, Petr Kavan, Neesha C. Dhani, Derek J. Jonker, Alice Chia-chi Wei, Tina Hsu, Patricia A. Tang, Barbara Graham, Dongsheng Tu, Christopher J. O'Callaghan Abstract Accrual of older adults to Canadian Cancer Trials Group-led trials: A retrospective analysis from 1990 to 2015 Session Title: Patient and Survivor Care Date: Saturday, June 3 Session Type: Poster Session Time: 1:15 PM - 4:45 PM Location: Hall A, Abstract #10031; Poster Board #20 Catalina Hernandez Torres, Winson Y. Cheung, Christopher J. O'Callaghan, Tina Hsu Abstract CCTG SC.24 - A randomized phase II/III study comparing stereotactic body radiotherapy versus conventional palliative radiotherapy for patients with spinal metastases Session Title: Patient and Survivor Care Date: Saturday, June 3 Session Type: Poster Session Time: 1:15 PM to 4:45 PM Location: Hall A, Abstract #TPS10129; Poster Board #115b Arjun Sahgal, Sten Myrehaug, Kristopher Dennis, Mitchell Liu, Edward Chow, Rebecca Wong, James B. Butler, Jeffrey Noah Greenspoon, Michael G Fehlings, Pejman Maralani, Laura Masucci, Young Lee, Michael Donald Brundage, Stanley K. Liu, Keyue Ding, Maaike Hum, Wendy R. Parulekar Abstract CCTG IND.226 - Immune-related adverse events with platinum chemotherapy with - durvalumab ± tremelimumab Session Title: Developmental Therapeutics – Immunotherapy Date: Monday, June 5 Session Type: Poster Session Time: 8:00 AM to 11:30 AM Location: Hall A, Abstract #3058; Poster Board #153 Nathalie Daaboul, Isabelle Gauthier, Dongsheng Tu, Pamela Brown-Walker, Xiaoqun Sun, Desiree Hao, Rosalyn A. Juergens, Penelope Ann Bradbury, Mihaela Mates, Mustapha Ali Tehfe, Christian K. Kollmannsberger, Peter Michael Ellis, Andrew George Robinson, Paul Wheatley-Price, Scott Andrew Laurie, Lesley Seymour Abstract Validation of RECIST 1.1 for use with cytotoxic agents and targeted cancer agents: Results of a RECIST Working Group analysis of a 50 clinical trials pooled individual patient database Session Title: Developmental Therapeutics – Clinical Pharmacology and Experimental Therapeutics Date: Monday, June 5 Session Type: Poster Session Time: 8:00 AM to 11:30 AM Location: Hall A; Abstract #2534; Poster Board #26 Saskia Litière, Gaëlle Isaac, Elisabeth De Vries, Jan Bogaerts, Alice P. Chen, Janet Dancey, Robert Ford, Steve J Gwyther, Otto S. Hoekstra, Erich Huang, Nancy U Lin, Yan Liu, Sumithra J. Mandrekar, Lawrence HOWARD Schwartz, Lalitha Shankar, Patrick Therasse, Lesley Seymour Abstract CCTG HN.6 - Resource utilization in patients with head and neck cancer: Analysis of CCTG HN.6 (NCT00820248) Session Title: Head and Neck Cancer Date: Monday, June 5 Session Type: Poster Session Time: 1:15 PM to 4:45 PM Location: Hall A, Abstract #6067; Poster Board #55 Ketan Ghate, Wendy R. Parulekar, Bingshu E. Chen, Alexander Montenegro, Nader Khaouam, Joy S. McCarthy, John Walker, John Waldron, Lillian L. Siu, Ana Johnson Abstract CCTG IND.209 - A randomized phase II study of -pelareorep plus docetaxel vs. docetaxel alone in patients with metastatic castration resistant prostate cancer Session Title: Genitourinary (Prostate) Cancer Date: Monday, June 5 Session Type: Poster Session Time: 1:15 PM to 4:45 PM Location: Hall A; Abstract #5021; Poster Board #95 Bernhard J. Eigl, Eric Winquist, Dongsheng Tu, Sebastien J. Hotte, Christina M. Canil, Richard William Gregg, Muhammad Zulfiqar, Scott A. North, Susan Ellard, Joseph D. Ruether, Lyly H. Le, Ankineedu Saranya Kakumanu, Ashley Theis, Christopher M. Booth, Kylea R. Potvin, Kim N. Chi, Lesley Seymour Abstract CCTG MAC.11/S0221 - SWOG S0221 updated: Randomized comparison of chemotherapy schedules in breast cancer adjuvant therapy. Session Title: Breast Cancer—Local/Regional/Adjuvant Date: Sunday, June 4 Session Type: Poster Session (Board #121) Time: 8:00 AM to 11:30 AM Location: Hall A - Abstract #521 G. Thomas Budd, William E. Barlow, Halle C. F. Moore, Timothy J. Hobday, James A. Stewart, Claudine Isaacs, Muhammad Salim, Jonathan K. Cho, Kristine Rinn, Kathy S. Albain, Helen K. Chew, Gary Von Burton, Timothy David Moore, Gordan Srkalovic, Bradley Alexander McGregor, Lawrence E. Flaherty, Robert B. Livingston, Danika L Lew, Julie Gralow, Gabriel N. Hortobagyi Abstract
