NCIC Clinical Trials Group

Brain Gastro-Intestinal Gynecologic Hematologic Lung Sarcoma
Breast Genito-Urinary Head & Neck IND Melanoma Symptom Control

IND Meeting Reports: 2008-2013

ID Site Study Title Status
IND.215 Phase Ib A Phase Ib Study of Selumetinib in Patients with Previously Treated or Untreated Advanced/ Metastatic NSCLC Who are Receiving Standard Chemotherapy Regimens    MORE... Cohort 1:
Open
Cohort 2:
Open
Cohort 3:
Planned
IND.213 Phase II A Randomized Phase II Study of Reolysin For Patients Receiving Standard Weekly Paclitaxel Therapy as Therapy For Advanced/Metastatic Breast Cancer    MORE... Open
IND.212 Phase I A Pilot Study of Imetelstat given Intravenously on Day 1 and 8 of a 21 Day Schedule Alone and With Standard 13-Cis-Retinoic Acid in Children with Recurrent and/or Refractory Neuroblastoma    MORE... Planned
IND.211 Phase II A Randomized Phase II Study of Reolysin in Patients With Previously Treated Advanced or Metastatic, Non Small Cell Lung Cancer Receiving Standard Salvage Therapy    MORE... Open
IND.210 Phase II A Randomized Phase II Study of Reolysin in Combination with FOLFOX6 and Bevacizumab or FOLFOX6 and Bevacizumab Alone in Patients with Metastatic Colorectal Cancer    MORE... Open
IND.209 Phase II A Randomized Phase II Study Of Reolysin® in Combination With Docetaxel and Prednisone or Docetaxel and Prednisone Alone in patients With Metastatic Castration Resistant Prostate Cancer    MORE... Open
IND.208 Phase I/II Phase I/II Study of the P13Kinase Inhibitor BKM120 Given in Combination with Panitumumab in Patients with Metastatic or Advanced RAS-Wild Type Colorectal Cancer    MORE... Open
IND.207 Phase II A Phase II Study of PF-03446962 in Patients with Advanced Malignant Pleural Mesothelioma    MORE... Open
IND.206 Phase II A Phase II Study of Sunitinib or Temsirolimus in Patients with Advanced Rare Tumours    MORE... Open
IND.205 Phase II A Phase II Study of PX-866 in Patients With Metastatic Castration Resistant Prostate Cancer (CRPC)    MORE... Part A - Closed
Part B -Open
IND.204 Phase II A Phase II Study of PX-866 in Patients With Glioblastoma Multiforme at Time of First Relapse or Progression    MORE... Closed
IND.203 Phase I A Phase I Study of SB939 in Pediatric Patients with Refractory Solid Tumours and Leukemia    MORE... Closed
IND.202 Phase II A Randomized Phase II Study of Interleukin-21 (rIL-21) versus Dacarbazine (DTIC) in Patients with Metastatic or Recurrent Melanoma    MORE... Closed
IND.200 Phase II A Phase II Study of SB939 in Patients with Translocation-Associated Recurrent/Metastatic Sarcomas    MORE... Closed
IND.199 Phase II A Phase II Study of Temsirolimus (NSC 683864), an mTOR Inhibitor, in Patients with Recurrent, Unresectable, Locally Advanced or Metastatic Carcimona of the Cervix    MORE... Closed
IND.198 Phase I/II A Phase I/II Study of Foretinib in Combination with Lapatinib in Patients with Human Epidermal Growth Factor Receptor (HER2) Over-Expressing Metastatic Breast Cancer    MORE... Closed
IND.197 Phase II A Phase II Study of Foretinib in Patients with Estrogen Receptor (ER), Progesterone Receptor (PR) and Human Epidermal Growth Factor Receptor 2 (HER2) Negative, Recurrent/Metastatic Breast Cancer    MORE... On Hold
IND.196 Phase I/II A Phase I/II Study of Foretinib in Patients with Previously Treated Non-Small Cell Lung Cancer Receiving Standard Erlotinib Therapy    MORE... Closed
IND.195 Phase II A Phase II Study of SB939 in Patients with Recurrent or Metastatic Castration Resistant Prostate Cancer    MORE... Closed
IND.194 Phase II A Phase II Study of AT7519M, a CDK Inhibitor, in Patients with Relapsed Mantle Cell Lymphoma    MORE... Open
IND.193 Phase II A Phase II Study of AT7519M, A CDK Inhibitor in Patients with Relapsed and/or Refractory Chronic Lymphocytic Leukemia    MORE... Open
IND.192 Phase II A Phase II Study of Ridaforolimus in Patients with Metastatic and/or Locally Advanced Recurrent Endometrial Cancer    MORE... Closed
IND.191 Phase II A Phase II Study of AT9283 in Patients with Relapsed or Refractory Multiple Myeloma    MORE... Closed
IND.190 Phase I/II A Phase I-II Trial of MK-0646, a Monoclonal Antibody Against Insulin-Like Growth Factor-1 Receptor in Combination with Etoposide and Cisplatin in Extensive Stage Small Cell Lung Cancer    MORE... Permanently Closed
IND.189 Phase II A Phase II Study of Interlukin-21 (Il-21) in Patients with Metastatic or Recurrent Malignant Melanoma    MORE... Permanently Closed
IND.188 Phase I A Clinical and Pharmacokinetic Study of Sb939 in Patients with Advanced Cancer    MORE... Permanently Closed
IND.187 Phase I A Phase I Study Of AZD2281 In Combination With Irinotecan In Patients With Locally Advanced or Metastatic Incurable Colorectal Cancer    MORE... Closed
IND.186 Phase I/II A Phase I/II Study of Sorafenib (BAY 43-9006) In Combination With Low Dose ARA-C (Cytarabine) In Elderly Patients With AML Or High-Risk MDS    MORE... Permanently Closed
IND.185 Gynecologic A Phase II Study of Sunitinib (SU11248; NSC 736511) in Patients with Recurrent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Carcinoma    MORE... Permanently Closed
IND.184 Gynecologic A Phase II Study of Sunitinib, an Oral Multi-Targeted Tyrosine Kinase Inhibitor, in Patients with Unresectable, Locally Advanced or Metastatic Cervical Carcinoma    MORE... Permanently Closed
IND.183 Phase II A Phase II Study of Sunitinib in Patients with Advanced Malignant Pleural Mesothelioma    MORE... Permanently Closed
IND.182 Hematologic A Phase II Study of Sunitinib (SU11248; NSC 736511; IND 74019), an Oral Multi-Targeted Tyrosine Kinase Inhibitor, in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma    MORE... Permanently Closed
IND.181 Phase I NCIC CTG Phase I Study of AT9283 Given as a 24 Hour Infusion on Days 1 and 8 Every Three Weeks in Patients with Advanced Incurable Malignancy    MORE... Permanently Closed
IND.179 Phase I A Phase I Study of CCI-779 in Combination with Carboplatin and Paclitaxel in Patients with Advanced Solid Tumours    MORE... Permanently Closed
IND.178 Phase I A Phase I Dose-Escalation Study Of JX-963 (Thymidine Kinase/Vaccinia Growth Factor Gene-Deleted Vaccinia Virus Plus GM-CSF) In Patients With Advanced Incurable Solid Tumours    MORE... Closed
IND.177 Phase I A Phase I Study of AT7519M Given Twice Weekly in Patients with Advanced Incurable Malignancy    MORE... Permanently Closed
IND.175 Phase I A Phase I, Open-Label, Dose-Seeking Study of AZD2171 Given Daily Orally in Combination with Selected Standard Chemotherapy Regimens (CT) in Patients with Advanced Incurable Non-Small Cell Lung Cancer (NSCLC) or Colorectal Cancer    MORE... Permanently Closed
IND.173 Phase I/II A Phase I/II Study of AZD0530 in Combination with Gemcitabine in Patients with Advanced Pancreatic Cancer    MORE... Permanently Closed
IND.172 Hematologic Phase II Study of Bortezomib and Gemcitabine in Patients with Relapsed Mantle Cell Lymphoma    MORE... Permanently Closed
IND.171 Phase I A Phase I, Open-Label, Dose-Seeking Study of AZD2171 Given Daily Orally in Combination with Standard Chemotherapy Regimens (CT) in Patients with Advanced Incurable Non-Small Cell Lung Cancer (NSCLC) or Colorectal Cancer or Other Tumour Types Suitable for Treatment with Capecitabine    MORE... Permanently Closed
IND.170 Phase I/II A Phase I/II Study of GW572016 in Patients with Recurrent Malignant Glioma    MORE... Permanently Closed
IND.169 Melanoma This is a Non-Randomized, Non-Blinded Multicentre Phase II Study of SB-715992 in Previously Untreated Patients with Metastatic or Recurrent Malignant Melanoma    MORE... Permanently Closed
IND.168 Phase II SB-715992 (NSC 727990) in Patients with Locally Advanced, Recurrent or Metastatic Hepatocellular Carcinoma    MORE... Permanently Closed
IND.167 Genito-Urinary Phase II Study of BAY 43-9006 (NSC 724772) in Patients with Hormone Refractory Prostate Cancer    MORE... Permanently Closed
IND.166B Phase I This is a Multi-Centre, Open-Label, Dose-Escalating Phase I Clinical Trial of AEG35156 in Combination with Docetaxel in Patients with Solid Tumours    MORE... Permanently Closed
IND.166 Phase I This is a Multi-Centre, Open-Label, Dose-Escalating Phase I Clinical Trial of AEG35156 in Combination with Docetaxel in Patients with Solid Tumours    MORE... Permanently Closed
IND.165 Genito-Urinary A Randomized Phase II Study of OGX-011 in Combination with Docetaxel and Prednisone or Docetaxel and Prednisone Alone in Patients with Metastatic Hormone Refractory Prostate Cancer    MORE... Permanently Closed
IND.164 Breast A Phase II Study of a Second Generation Clusterin Antisense Oligonucleotide (OGX-011) in Combination with Docetaxel in Advanced Breast Cancer    MORE... Permanently Closed
IND.163 Breast A Randomized Phase II Study of Two Different Schedules of RAD001C in Patients with Recurrent/Metastatic Breast Cancer    MORE... Permanently Closed
IND.162 Phase I A Phase I Study of Temozolomide and RAD001C in Patients with Malignant Glioma    MORE... Permanently Closed
IND.160 Gynecologic A Phase II Study Of CCI-779 in Patients with Metastatic and/or Locally Advanced Recurrent Endometrial Cancer    MORE... Permanently Closed

Use this to link back to CTG home only

If you have any questions, comments or suggestions, please contact our