NCIC Clinical Trials Group

Brain Gastro-Intestinal Gynecologic Hematologic Lung Sarcoma
Breast Genito-Urinary Head & Neck IND Melanoma Symptom Control

Spring Meeting Trial Reports: 2011 / 2010 / 2009
ID Study Title Status
IND.172 Phase II Study of Bortezomib and Gemcitabine in Patients with Relapsed Mantle Cell Lymphoma    MORE... Closed
IND.182 A Phase II Study of Sunitinib (SU11248; NSC 736511; IND 74019), an Oral Multi-Targeted Tyrosine Kinase Inhibitor, in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma    MORE... Closed
IND.186 A Phase I/II Study of Sorafenib (BAY 43-9006) In Combination With Low Dose ARA-C (Cytarabine) In Elderly Patients With AML Or High-Risk MDS    MORE... Closed
IND.191 A Phase II Study of AT9283 in Patients with Relapsed or Refractory Multiple Myeloma    MORE... Open
IND.193 A Phase II Study of AT7519M, A CDK Inhibitor in Patients with Relapsed and/or Refractory Chronic Lymphocytic Leukemia    MORE... Planned
AL.3 Phase III Randomized Study of Concurrent Tretinoin and Chemotherapy with or without Arsenic Trioxide (AS2O3) (NSC # 706363) as Initial Consolidation Therapy Followed by Maintenance Therapy with Intermittent Tretinoin vs Intermittent Tretinoin plus Mercaptopurine and Methotrexate for Patients with Untreated Acute Promyelocytic Leukemia    MORE... Closed
AL.4 A Multi-Center Phase II Study in Adults with Untreated Acute Lymphoblastic Leukemia: Testing Pharmacokinetically Individualized Doses of L-Asparaginase Following the DFCI Pediatric Consortium Protocol    MORE... Closed
AL.5 A Phase II Study of Adult ALL Trial    MORE... Open
ALC.1 A Phase III Study of the Addition of Gemtuzumab Ozogamicin (Mylotarg®) During Induction Therapy Versus Standard Induction with Daunomycin and Cytosine Arabinoside Followed by Consolidation and Subsequent Randomization to Post-Consolidation Therapy with Gemtuzumab Ozogamicin (Mylotarg®) or No Additional Therapy For Patients Under Age 61 with Previously Untreated De Novo Acute Myeloid Leukemia (AML)    MORE... Closed
ALC.2 A Phase III Randomized, Double-Blind Study of Induction (Daunorubicin/Cytarabine) and Consolidation (High-Dose Cytarabine) and Consolidation (High-Dose Cytarabine) Chemotherapy + Midostaurin (PK412) (IND # 101261) or Placebo in Newly Diagnosed Patients < 60 Years of Age with FLT3 Mutated Acute Myeloid Leukemia (AML)    MORE... Closed
CL.2 A Phase II Study of Oral Fludarabine Phosplate in Patients with Previously Untreated B-cell Chronic Lymphocytic Leukemia    MORE... Permanently Closed
CL.3 A Genetic, Risk-Stratified Randomized Phase II Study of Four Fludarabine/Antibody Combinations For Patients with Symptomatic Previously Untreated Chronic Lymphocytic Leukemia    MORE... Open
CLC.1 A Phase III Intergroup CLL Study Of Asymptomatic Patients with Untreated Chronic Lymphocytic Leukemia Randomized to Early Intervention versus Observation with Later Treatment in the High Risk Genetic Subset with IGVH Unmutated Disease    MORE... Closed
CM.1 A Phase IIb Study of Molecular Responses to Imatinib at Standard or Increased Doses for or Dasatinib (BMS 354825) (NSC-732517) for Previously Untreated Patients with Chronic Myelogenous Leukemia (CML) in Chronic Phase    MORE... Closed
HD.6 A Phase III Study of Radiotherapy or ABVD plus Radiotherapy versus ABVD Alone in the Treatment of Early Stage Hodgkin's Disease    MORE... Permanently Closed
HD.7 A Randomized Phase III Trial of ABVD versus Stanford V with or without Radiation Therapy in Locally Extensive and Advanced Stage Hodgkin's Disease    MORE... Closed
HD.8 BEACOPP (4 cycles escalated + 4 cycles baseline) versus ABVD (8 cycles) in stage III & IV Hodgkin's lymphoma    MORE... Closed
LY.7 Chimeric Anti-CD20 Monoclonal Antibody (Rituximab)in Remission Induction and Maintenance Treatment of Relapsed Follicular Non-Hodgkins Lymphoma. A Phase III Randomized Clinical Trial    MORE... Closed
LY.9 Randomised Intergroup Trial of First Line Treatment for Patients with Diffuse Large B-Cell Non-Hodgkins Lymphoma with a CHOP-like Chemotherapy Regimen with or without the Anti-CD20 Antibody Rituximab (IDEC-C2B8)    MORE... Closed
LY.10 A Phase II Study of Gemcitabine, Dexamethasone, and Cisplatin (GDP) in Patients with Either Hodgkin's Disease or Aggressive Histology Non-Hodgkin's Lymphoma Which Is Relapsed or Refractory    MORE... Permanently Closed
LY.11 A Randomized Phase III Trial Comparing Early High Dose Chemoradiotherapy and an Autologous Stem Cell Transplant to Conventional Dose CHOP Chemotherapy plus Rituximab for CD20+B-Cell Lymphomas (with Possible Late Autologous Stem Cell Transplant)for Patients with Diffuse Aggressive Non-Hodgkin's Lymphoma in the High-Intermediate/High Risk International Classification Prognostic Groups    MORE... Closed
LY.12 A Phase III Study of Gemcitabine, Dexamethasone, and Cisplatin Compared to Dexamethasone, Cytarabine, and Cisplatin plus/minus Rituximab as Salvage Chemotherapy for Patients with Relapsed or Refractory Aggressive Histology Non-Hodgkin'sLymphoma Prior to Autologous Stem Cell Transplant and Followed by Maintenance Rituximab versus Observation    MORE... Closed
LY.13 A Multi-centre Phase II Trial Investigating the Efficacy and Tolerability of Bortezomib Added to Cyclophosphamide, Vincristine, Prednisone and Rituximab (BCVP-R) for Patients with Advanced Stage Follicular Non-Hodgkin's Lymphoma Requiring Systemic First-Line Treatment    MORE... Permanently Closed
MY.7 A Comparative Study of Dexamethasone versus Prednisone (Both In Combination with Melphalan) As Induction Therapy in Untreated Symptomatic Myeloma with an Additional Assessment of Dexamethasone versus No Additional Treatment as Maintenance Therapy    MORE... Permanently Closed
MY.10 A Randomized Phase III Study of Thalidomide and Prednisone as Maintenance Therapy Following Autologous Stem Cell Transplant in Patients with Multiple Myeloma    MORE... Closed
MY.11 A Randomized Phase II Dose Finding Study of Lenalidomide and Melphalan in Patients with Previously Untreated Multiple Myeloma    MORE... Permanently Closed

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